ID   CXA5_CHICK              Reviewed;         369 AA.
AC   P18860;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Gap junction alpha-5 protein;
DE   AltName: Full=Connexin-42;
DE            Short=Cx42;
GN   Name=GJA5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2167316; DOI=10.1016/s0021-9258(18)77321-3;
RA   Beyer E.C.;
RT   "Molecular cloning and developmental expression of two chick embryo gap
RT   junction proteins.";
RL   J. Biol. Chem. 265:14439-14443(1990).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Mostly in heart, and in the whole embryo, liver,
CC       stomach, and pectoral muscle.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M35043; AAA48716.1; -; mRNA.
DR   PIR; B37819; B37819.
DR   AlphaFoldDB; P18860; -.
DR   SMR; P18860; -.
DR   STRING; 9031.ENSGALP00000024929; -.
DR   PaxDb; P18860; -.
DR   VEuPathDB; HostDB:geneid_396502; -.
DR   eggNOG; ENOG502QW11; Eukaryota.
DR   InParanoid; P18860; -.
DR   PhylomeDB; P18860; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002264; Connexin40.
DR   InterPro; IPR034634; Connexin_C.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   InterPro; IPR031862; Cx40_C.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   PANTHER; PTHR11984:SF13; PTHR11984:SF13; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   Pfam; PF16791; Connexin40_C; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01135; CONNEXINA5.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   SUPFAM; SSF118220; SSF118220; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..369
FT                   /note="Gap junction alpha-5 protein"
FT                   /id="PRO_0000057822"
FT   TOPO_DOM        2..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..210
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          347..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41745 MW;  18D7A242765E0EC4 CRC64;
     MGDWSFLGEF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AGPLWGDEQS DFMCDTQQPG
     CENVCYDKAF PISHVRFWVL QIIFVSTPSL VYMGHAMHTV RMEEKRKMKE AEREAQEMKN
     SGDTYYQQKC PVAEKTELSC WDESGGKIIL RGSLLNTYVY SILIRTAMEI AFIVGQYILY
     GIFLETLYIC QRAPCPHPVN CYVSRPTEKN VFIIFMLAVA VLSLFLSLAE LYHLGWKKAK
     ERCSRAYKPS PSTAPRRLES APQVERAQMY TPPPDFNQCL ASPNGKFISP FSNKMASQQN
     TANFATERVH SQEDAAGEGP FMKSSYMESP EVASECAAPA LPESYFNEKR RFSKASRASS
     KARSDDLSV