ID   CXA6_RAT                Reviewed;         286 AA.
AC   P28233;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Gap junction alpha-6 protein;
DE   AltName: Full=Connexin-33;
DE            Short=Cx33;
GN   Name=Gja6; Synonyms=Cxn-33;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1370487; DOI=10.1016/s0021-9258(18)46052-8;
RA   Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA   Paul D.L.;
RT   "Four novel members of the connexin family of gap junction proteins.
RT   Molecular cloning, expression, and chromosome mapping.";
RL   J. Biol. Chem. 267:2057-2064(1992).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Expressed in testis.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M76534; AAA40998.1; -; Genomic_DNA.
DR   PIR; C42053; C42053.
DR   RefSeq; NP_062181.1; NM_019308.1.
DR   AlphaFoldDB; P28233; -.
DR   SMR; P28233; -.
DR   Ensembl; ENSRNOT00000115489; ENSRNOP00000085747; ENSRNOG00000069341.
DR   GeneID; 54256; -.
DR   KEGG; rno:54256; -.
DR   UCSC; RGD:2693; rat.
DR   CTD; 414089; -.
DR   RGD; 2693; Gja6.
DR   GeneTree; ENSGT01050000244914; -.
DR   InParanoid; P28233; -.
DR   OrthoDB; 1172752at2759; -.
DR   PhylomeDB; P28233; -.
DR   PRO; PR:P28233; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..286
FT                   /note="Gap junction alpha-6 protein"
FT                   /id="PRO_0000057824"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..209
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..286
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   286 AA;  32860 MW;  A585266ACA2ACCF2 CRC64;
     MSDWSALHQL LEKVQPYSTA GGKVWIKVLF IFRILLLGTA IESAWSDEQF EFHCNTQQPG
     CENVCYDQAF PISHVRLWVL QVIFVSVPTL LHLAHVYYVI RQNEKLKKQE EEELKVAHFN
     GASGERRLQK HTGKHIKCGS KEHGNRKMRG RLLLTYMASI FFKSVFEVAF LLIQWYLYGF
     TLSAVYICEQ SPCPHRVDCF LSRPTEKTIF ILFMLVVSMV SFVLNVIELF YVLFKAIKNH
     LGNEKEEVYC NPVELQKPSC VSSSAVLTTI CSSDQVVPVG LSSFYM