ID   CXB1_XENLA              Reviewed;         264 AA.
AC   P08983;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Gap junction beta-1 protein;
DE   AltName: Full=Connexin-30;
DE            Short=Cx30;
GN   Name=gjb1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2843548; DOI=10.1083/jcb.107.3.1065;
RA   Gimlich R.L., Kumar N.M., Gilula N.B.;
RT   "Sequence and developmental expression of mRNA coding for a gap junction
RT   protein in Xenopus.";
RL   J. Cell Biol. 107:1065-1073(1988).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Lung, liver, intestines, stomach and kidney.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; Y00791; CAA68745.1; -; mRNA.
DR   PIR; A31102; A31102.
DR   RefSeq; NP_001095219.1; NM_001101749.1.
DR   AlphaFoldDB; P08983; -.
DR   SMR; P08983; -.
DR   GeneID; 394373; -.
DR   KEGG; xla:394373; -.
DR   CTD; 394373; -.
DR   Xenbase; XB-GENE-865435; gjb1.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 394373; Expressed in neurula embryo and 14 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002267; Connexin32.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01138; CONNEXINB1.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="Gap junction beta-1 protein"
FT                   /id="PRO_0000057853"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29995 MW;  08082E1F1051A8B8 CRC64;
     MNWAGLYAIL SGVNRHSTSI GRIWLSVVFI FRIMVLVAAA ESVWGDEKSA FTCNTQQPGC
     NSVCYDHFFP ISHIRLWALQ LIIVSTPALL VAMHVAHLQH QEKKELRLSR HVKDQELAEV
     KKHKVKISGT LWWTYISSVF FRIIFEAAFM YIFYLIYPGY SMIRLLKCDA YPCPNTVDCF
     VSRPTEKTIF TVFMLVASGV CIVLNVAEVF FLIAQACTRR ARRHRDSGSI SKEHQQNEMN
     LLITGGSIIK RSAGQEKGDH CSTS