ID   CXB2_BOVIN              Reviewed;         226 AA.
AC   A2VE67;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Gap junction beta-2 protein;
DE   AltName: Full=Connexin-26;
DE            Short=Cx26;
GN   Name=GJB2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC       with CNST (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC133597; AAI33598.1; -; mRNA.
DR   RefSeq; NP_001077106.1; NM_001083637.2.
DR   AlphaFoldDB; A2VE67; -.
DR   SMR; A2VE67; -.
DR   STRING; 9913.ENSBTAP00000023167; -.
DR   PaxDb; A2VE67; -.
DR   PRIDE; A2VE67; -.
DR   Ensembl; ENSBTAT00000023167; ENSBTAP00000023167; ENSBTAG00000017425.
DR   GeneID; 407154; -.
DR   KEGG; bta:407154; -.
DR   CTD; 2706; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017425; -.
DR   VGNC; VGNC:29377; GJB2.
DR   eggNOG; ENOG502QWM8; Eukaryota.
DR   GeneTree; ENSGT01030000234513; -.
DR   HOGENOM; CLU_037388_4_1_1; -.
DR   InParanoid; A2VE67; -.
DR   OMA; RKFMKGE; -.
DR   OrthoDB; 1043502at2759; -.
DR   TreeFam; TF329606; -.
DR   Reactome; R-BTA-190872; Transport of connexons to the plasma membrane.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000017425; Expressed in rumen papilla and 87 other tissues.
DR   GO; GO:0005922; C:connexin complex; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:1903763; F:gap junction channel activity involved in cell communication by electrical coupling; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR   GO; GO:0016264; P:gap junction assembly; IEA:Ensembl.
DR   GO; GO:1990349; P:gap junction-mediated intercellular transport; ISS:UniProtKB.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002268; Connexin26.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01139; CONNEXINB2.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Disulfide bond; Gap junction; Hearing;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Gap junction beta-2 protein"
FT                   /id="PRO_0000313008"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..180
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..174
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..169
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   226 AA;  26194 MW;  7C8D0A7847EEC5A9 CRC64;
     MDWGGLHTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC
     KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYYRH EKKRKFIRGE IKTEFKDIEE
     IKKQKVRIEG SLWWTYTGSI FFRVIFEAAF MYVFYVMYDG FAMQRLVKCN AWPCPNTVDC
     FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRFCSG KSKKPV