ID   CXB3_BOVIN              Reviewed;         270 AA.
AC   Q58D78; A2VDS2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Gap junction beta-3 protein;
DE   AltName: Full=Connexin-31;
DE            Short=Cx31;
GN   Name=GJB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC       with CNST (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BT021719; AAX46566.1; -; mRNA.
DR   EMBL; BC133376; AAI33377.1; -; mRNA.
DR   RefSeq; NP_001098465.1; NM_001104995.1.
DR   RefSeq; XP_005204874.1; XM_005204817.3.
DR   AlphaFoldDB; Q58D78; -.
DR   SMR; Q58D78; -.
DR   STRING; 9913.ENSBTAP00000016705; -.
DR   PaxDb; Q58D78; -.
DR   PRIDE; Q58D78; -.
DR   Ensembl; ENSBTAT00000016705; ENSBTAP00000016705; ENSBTAG00000012584.
DR   GeneID; 539935; -.
DR   KEGG; bta:539935; -.
DR   CTD; 2707; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012584; -.
DR   VGNC; VGNC:29378; GJB3.
DR   eggNOG; ENOG502QRC0; Eukaryota.
DR   GeneTree; ENSGT01030000234513; -.
DR   HOGENOM; CLU_037388_4_1_1; -.
DR   InParanoid; Q58D78; -.
DR   OMA; CIVLTVC; -.
DR   OrthoDB; 902090at2759; -.
DR   TreeFam; TF329606; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000012584; Expressed in placenta and 50 other tissues.
DR   ExpressionAtlas; Q58D78; baseline.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002269; Connexin31.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   PANTHER; PTHR11984:SF65; PTHR11984:SF65; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01140; CONNEXINB3.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Gap junction beta-3 protein"
FT                   /id="PRO_0000239111"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        237
FT                   /note="S -> C (in Ref. 1; AAX46566)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   270 AA;  31016 MW;  7F94EE1B34CAF07C CRC64;
     MDWKTLQALL SGVNKYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD FDCNTKQPGC
     TNVCYDEFFP ISNIRLWALQ LIFVTCPSLL VILHVAYREE RERRHRQKHG DQCTKLYDDT
     GKKHGGLWWT YLLSLVFKLL IEFLFLYLLH TLWYGFGMPR LVQCANVAPC PNTVDCYIAR
     PTEKKLFTYF MVGASAVCIV LTFCEICYLI FHRVVRSLHR KRQPGGRGHA PSASRASTCR
     CHHKLLEAGD LSPDSHDNKL CASAPTMTPI