ID   CXB3_RAT                Reviewed;         270 AA.
AC   P25305;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Gap junction beta-3 protein;
DE   AltName: Full=Connexin-31;
DE            Short=Cx31;
GN   Name=Gjb3; Synonyms=Cxn-31;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1706719; DOI=10.1016/s0021-9258(18)38149-3;
RA   Hoh J.H., John S.A., Revel J.-P.;
RT   "Molecular cloning and characterization of a new member of the gap junction
RT   gene family, connexin-31.";
RL   J. Biol. Chem. 266:6524-6531(1991).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC       with CNST (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M59936; AAA40997.1; -; Genomic_DNA.
DR   PIR; A38737; A38737.
DR   RefSeq; NP_062113.1; NM_019240.1.
DR   RefSeq; XP_006238907.1; XM_006238845.3.
DR   AlphaFoldDB; P25305; -.
DR   SMR; P25305; -.
DR   STRING; 10116.ENSRNOP00000019266; -.
DR   iPTMnet; P25305; -.
DR   PhosphoSitePlus; P25305; -.
DR   PaxDb; P25305; -.
DR   Ensembl; ENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372.
DR   Ensembl; ENSRNOT00000111000; ENSRNOP00000084913; ENSRNOG00000014372.
DR   GeneID; 29585; -.
DR   KEGG; rno:29585; -.
DR   UCSC; RGD:2695; rat.
DR   CTD; 2707; -.
DR   RGD; 2695; Gjb3.
DR   eggNOG; ENOG502QRC0; Eukaryota.
DR   GeneTree; ENSGT01030000234513; -.
DR   HOGENOM; CLU_037388_4_1_1; -.
DR   InParanoid; P25305; -.
DR   OMA; CIVLTVC; -.
DR   OrthoDB; 902090at2759; -.
DR   PhylomeDB; P25305; -.
DR   TreeFam; TF329606; -.
DR   Reactome; R-RNO-190861; Gap junction assembly.
DR   PRO; PR:P25305; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000014372; Expressed in jejunum and 11 other tissues.
DR   Genevisible; P25305; RN.
DR   GO; GO:0005911; C:cell-cell junction; ISO:RGD.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005921; C:gap junction; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; IEP:RGD.
DR   GO; GO:0001890; P:placenta development; ISO:RGD.
DR   GO; GO:0043588; P:skin development; IEP:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IEP:RGD.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002269; Connexin31.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   PANTHER; PTHR11984:SF65; PTHR11984:SF65; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01140; CONNEXINB3.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   3: Inferred from homology;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Gap junction beta-3 protein"
FT                   /id="PRO_0000057864"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..270
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   270 AA;  30969 MW;  3D0C506FCE179C44 CRC64;
     MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD FDCNTRQPGC
     TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE RERKHRQKHG EHCAKLYSHP
     GKKHGGLWWT YLFSLIFKLI IELVFLYVLH TLWHGFTMPR LVQCASVVPC PNTVDCYIAR
     PTEKKVFTYF MVGASAVCII LTICEICYLI FHRIMRGLSK DKSTKSISSP KSSSRASTCR
     CHHKLLESGD LEAVPADDKL QASAPSLTPI