CXB5_MOUSE
ID CXB5_MOUSE Reviewed; 271 AA.
AC Q02739;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Gap junction beta-5 protein;
DE AltName: Full=Connexin-31.1;
DE Short=Cx31.1;
GN Name=Gjb5; Synonyms=Cxn-31.1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=1512260; DOI=10.1016/s0021-9258(18)41916-3;
RA Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S.,
RA Nicholson B.J., Willecke K.;
RT "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on
RT mouse chromosome 4 and preferentially expressed in skin.";
RL J. Biol. Chem. 267:17225-17233(1992).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- TISSUE SPECIFICITY: Expressed in skin, much lower in testis.
CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC subfamily. {ECO:0000305}.
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DR EMBL; M91236; AAA37426.1; -; mRNA.
DR EMBL; M91442; AAA37427.1; -; Genomic_DNA.
DR CCDS; CCDS18670.1; -.
DR PIR; B43433; B43433.
DR RefSeq; NP_034421.1; NM_010291.3.
DR AlphaFoldDB; Q02739; -.
DR SMR; Q02739; -.
DR STRING; 10090.ENSMUSP00000045325; -.
DR iPTMnet; Q02739; -.
DR PhosphoSitePlus; Q02739; -.
DR PaxDb; Q02739; -.
DR PRIDE; Q02739; -.
DR ProteomicsDB; 279218; -.
DR Antibodypedia; 31495; 165 antibodies from 25 providers.
DR DNASU; 14622; -.
DR Ensembl; ENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
DR GeneID; 14622; -.
DR KEGG; mmu:14622; -.
DR UCSC; uc008uuv.1; mouse.
DR CTD; 2709; -.
DR MGI; MGI:95723; Gjb5.
DR VEuPathDB; HostDB:ENSMUSG00000042357; -.
DR eggNOG; ENOG502R3YE; Eukaryota.
DR GeneTree; ENSGT01030000234513; -.
DR HOGENOM; CLU_037388_4_1_1; -.
DR InParanoid; Q02739; -.
DR OMA; HSFYPKY; -.
DR OrthoDB; 955506at2759; -.
DR PhylomeDB; Q02739; -.
DR TreeFam; TF329606; -.
DR Reactome; R-MMU-190861; Gap junction assembly.
DR BioGRID-ORCS; 14622; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q02739; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q02739; protein.
DR Bgee; ENSMUSG00000042357; Expressed in ectoplacental cone and 51 other tissues.
DR ExpressionAtlas; Q02739; baseline and differential.
DR Genevisible; Q02739; MM.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:1905867; P:epididymis development; IEA:Ensembl.
DR GO; GO:0060713; P:labyrinthine layer morphogenesis; IMP:MGI.
DR GO; GO:0060708; P:spongiotrophoblast differentiation; IMP:MGI.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002271; Connexin311.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01141; CONNEXINB4.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..271
FT /note="Gap junction beta-5 protein"
FT /id="PRO_0000057869"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 271 AA; 31195 MW; F8732F5A8F5CD51A CRC64;
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD FDCNTRQPGC
TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA REKKYQEKIG EGYLYPNPGK
KRGGLWWTYV FSLSFKATID IIFLYLFHAF YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE
KNIFIVFMVV TAVICILLNL VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD
FLSCDLIFLG SDAHPPLLPD RPRAHVKKTI L
