CXB5_RAT
ID CXB5_RAT Reviewed; 271 AA.
AC P28232;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Gap junction beta-5 protein;
DE AltName: Full=Connexin-31.1;
DE Short=Cx31.1;
GN Name=Gjb5; Synonyms=Cxn-31.1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1370487; DOI=10.1016/s0021-9258(18)46052-8;
RA Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Paul D.L.;
RT "Four novel members of the connexin family of gap junction proteins.
RT Molecular cloning, expression, and chromosome mapping.";
RL J. Biol. Chem. 267:2057-2064(1992).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- TISSUE SPECIFICITY: Expressed in skin.
CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC subfamily. {ECO:0000305}.
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DR EMBL; M76533; AAB38538.1; -; Genomic_DNA.
DR PIR; D42053; D42053.
DR RefSeq; NP_062114.1; NM_019241.1.
DR RefSeq; XP_008762212.1; XM_008763990.1.
DR RefSeq; XP_017448696.1; XM_017593207.1.
DR AlphaFoldDB; P28232; -.
DR SMR; P28232; -.
DR STRING; 10116.ENSRNOP00000019315; -.
DR PaxDb; P28232; -.
DR Ensembl; ENSRNOT00000081919; ENSRNOP00000075127; ENSRNOG00000059897.
DR GeneID; 29586; -.
DR KEGG; rno:29586; -.
DR UCSC; RGD:2696; rat.
DR CTD; 2709; -.
DR RGD; 2696; Gjb5.
DR eggNOG; ENOG502R3YE; Eukaryota.
DR GeneTree; ENSGT01030000234513; -.
DR HOGENOM; CLU_037388_4_1_1; -.
DR InParanoid; P28232; -.
DR OMA; HSFYPKY; -.
DR OrthoDB; 955506at2759; -.
DR PhylomeDB; P28232; -.
DR TreeFam; TF329606; -.
DR Reactome; R-RNO-190861; Gap junction assembly.
DR PRO; PR:P28232; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000059897; Expressed in esophagus and 11 other tissues.
DR Genevisible; P28232; RN.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:1905867; P:epididymis development; IEP:RGD.
DR GO; GO:0060713; P:labyrinthine layer morphogenesis; ISO:RGD.
DR GO; GO:0060708; P:spongiotrophoblast differentiation; ISO:RGD.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; ISO:RGD.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002271; Connexin311.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01141; CONNEXINB4.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..271
FT /note="Gap junction beta-5 protein"
FT /id="PRO_0000057870"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 217..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 31047 MW; 7753FC96909015CE CRC64;
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD FDCNTRQPGC
TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA REKKYQQEVG KGYLYPNPGK
KRGGLWWTYV CSLLFKATID IIFLYLFHAF YPRYTLPSMV KCHSAPCPNT VDCFIAKPSE
KNIFIVFMLV TAIVCILLNL VELLYLVIKR CSECAPAKRP PTAHAKNDPN WANPSSKEKD
FLSSDLIFLG SDTHPPLLPD RPRAHVKKTI L
