ID   CXB6_BOVIN              Reviewed;         261 AA.
AC   Q5E9Z5; Q08E41;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Gap junction beta-6 protein;
GN   Name=GJB6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC       with CNST (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT020774; AAX08791.1; -; mRNA.
DR   EMBL; BC123433; AAI23434.1; -; mRNA.
DR   RefSeq; NP_001015546.1; NM_001015546.1.
DR   RefSeq; NP_001153649.1; NM_001160177.1.
DR   RefSeq; XP_005213824.1; XM_005213767.3.
DR   RefSeq; XP_005213825.1; XM_005213768.3.
DR   RefSeq; XP_005213826.1; XM_005213769.3.
DR   AlphaFoldDB; Q5E9Z5; -.
DR   SMR; Q5E9Z5; -.
DR   STRING; 9913.ENSBTAP00000052852; -.
DR   PaxDb; Q5E9Z5; -.
DR   PRIDE; Q5E9Z5; -.
DR   Ensembl; ENSBTAT00000052057; ENSBTAP00000052852; ENSBTAG00000038662.
DR   GeneID; 508454; -.
DR   KEGG; bta:508454; -.
DR   CTD; 10804; -.
DR   VEuPathDB; HostDB:ENSBTAG00000038662; -.
DR   VGNC; VGNC:29381; GJB6.
DR   eggNOG; ENOG502QWM8; Eukaryota.
DR   GeneTree; ENSGT01030000234513; -.
DR   HOGENOM; CLU_037388_4_1_1; -.
DR   InParanoid; Q5E9Z5; -.
DR   OMA; PNHAIKE; -.
DR   OrthoDB; 1043502at2759; -.
DR   TreeFam; TF329606; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000038662; Expressed in surface of tongue and 73 other tissues.
DR   ExpressionAtlas; Q5E9Z5; baseline and differential.
DR   GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR   GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:1903763; F:gap junction channel activity involved in cell communication by electrical coupling; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:0042471; P:ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0016264; P:gap junction assembly; IEA:Ensembl.
DR   GO; GO:1990349; P:gap junction-mediated intercellular transport; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Hearing; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Gap junction beta-6 protein"
FT                   /id="PRO_0000244878"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   261 AA;  30229 MW;  3FAC8D34508348AB CRC64;
     MDWGTLHTFV GGVNKHSTSI GKVWVTVLFV FRVMILVVAA QEVWGDEQED FVCNTLQPGC
     RNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH EAARRFRRGE TRSEFKDLED
     IKRQKVRIEG SLWWTYTSSI FFRIVFEAAF MYVFYFLYNG YHLPWVLKCG IQPCPNLVDC
     FISRPTEKTV FTIFMISASV ICMLLNVAEL CYLLLKVCFR RSKRAQTQKA PPNHALKESK
     QNEMNELISE GGQNAITGFP S