CXB6_CHICK
ID CXB6_CHICK Reviewed; 263 AA.
AC O93533;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Gap junction beta-6 protein;
DE AltName: Full=Connexin-31;
DE Short=Cx31;
GN Name=GJB6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000312|EMBL:AAC64043.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=White leghorn; TISSUE=Basilar papilla;
RX PubMed=9736748; DOI=10.1073/pnas.95.19.11400;
RA Heller S., Sheane C.A., Javed Z., Hudspeth A.J.;
RT "Molecular markers for cell types of the inner ear and candidate genes for
RT hearing disorders.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000255|RuleBase:RU000630, ECO:0000305}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000255|RuleBase:RU000630, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the cochlea of the inner
CC ear, where it is found in cells of the tegmentum vasculosum, cuboidal
CC cells, supporting cells and clear cells. {ECO:0000269|PubMed:9736748}.
CC -!- DEVELOPMENTAL STAGE: Specifically expressed at the late developmental
CC stages in the cochlea. {ECO:0000269|PubMed:9736748}.
CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC subfamily. {ECO:0000305}.
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DR EMBL; AF072699; AAC64043.1; -; mRNA.
DR RefSeq; NP_990262.1; NM_204931.1.
DR RefSeq; XP_015133175.1; XM_015277689.1.
DR RefSeq; XP_015133180.1; XM_015277694.1.
DR RefSeq; XP_015133186.1; XM_015277700.1.
DR AlphaFoldDB; O93533; -.
DR SMR; O93533; -.
DR STRING; 9031.ENSGALP00000027628; -.
DR PaxDb; O93533; -.
DR Ensembl; ENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136.
DR Ensembl; ENSGALT00000103505; ENSGALP00000066131; ENSGALG00000017136.
DR GeneID; 395771; -.
DR KEGG; gga:395771; -.
DR CTD; 10804; -.
DR VEuPathDB; HostDB:geneid_395771; -.
DR eggNOG; ENOG502QWM8; Eukaryota.
DR GeneTree; ENSGT01030000234513; -.
DR HOGENOM; CLU_037388_4_1_1; -.
DR InParanoid; O93533; -.
DR OMA; CYLIGKA; -.
DR OrthoDB; 1043502at2759; -.
DR PhylomeDB; O93533; -.
DR TreeFam; TF329606; -.
DR Reactome; R-GGA-190861; Gap junction assembly.
DR Reactome; R-GGA-190872; Transport of connexons to the plasma membrane.
DR PRO; PR:O93533; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000017136; Expressed in kidney and 10 other tissues.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Hearing; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..263
FT /note="Gap junction beta-6 protein"
FT /id="PRO_0000057873"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 30923 MW; D809506A6DB628BA CRC64;
MDWGALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA ERVWGDEQDD FICNTLQPGC
KNVCYDHFFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRQFRKGD QKCEYKDIEE
IRTQRFRIEG TLWWTYTCSI FFRLVFEAVF MYAFYFMYDG FRMPRLMKCS AWPCPNTVDC
FVSRPTEKTV FTIFMIAVSS ICILLNVAEL CYLLTKFFLR RSRKAGNQKH HPNHENKEET
KQNEMNELIS DSCQNTVIGF TSS
