ID   CXCL1_HCMVM             Reviewed;         120 AA.
AC   F5HBX1;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Chemokine vCXCL1;
GN   Name=UL146;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION.
RC   STRAIN=Toledo;
RX   PubMed=10449781; DOI=10.1073/pnas.96.17.9839;
RA   Penfold M.E., Dairaghi D.J., Duke G.M., Saederup N., Mocarski E.S.,
RA   Kemble G.W., Schall T.J.;
RT   "Cytomegalovirus encodes a potent alpha chemokine.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:9839-9844(1999).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH CXCR1 AND CXCR2.
RX   PubMed=20044480; DOI=10.1074/jbc.m109.002774;
RA   Luttichau H.R.;
RT   "The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2
RT   as an agonist.";
RL   J. Biol. Chem. 285:9137-9146(2010).
CC   -!- FUNCTION: Acts as a functional chemokine, inducing calcium
CC       mobilization, chemotaxis, and degranulation of neutrophils. Contributes
CC       to the induction of neutrophil chemotaxis by interacting with host
CC       CXCR1 and CXCR2 receptors. {ECO:0000269|PubMed:10449781,
CC       ECO:0000269|PubMed:20044480}.
CC   -!- SUBUNIT: Interacts with host CXCR1 and CXCR2.
CC       {ECO:0000269|PubMed:20044480}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY446894; AAR31675.1; -; Genomic_DNA.
DR   RefSeq; YP_081571.1; NC_006273.2.
DR   PRIDE; F5HBX1; -.
DR   DNASU; 3077566; -.
DR   GeneID; 3077566; -.
DR   KEGG; vg:3077566; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0039553; P:suppression by virus of host chemokine activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Inhibition of host chemokines by virus;
KW   Reference proteome; Viral immunoevasion.
FT   CHAIN           1..120
FT                   /note="Chemokine vCXCL1"
FT                   /id="PRO_0000418259"
SQ   SEQUENCE   120 AA;  13872 MW;  D5247AF226EA2093 CRC64;
     MRLIFGALII SLTYMYYYEV HGTELRCKCL DGKKLPPKTI MLGNFWFHRE SGGPRCNNNE
     YFLYLGGGKK HGPGVCLSPH HPFSKWLDKR NDNRWYNVNV TRQPERGPGK ITVTLVGLKE