CXCL3_MOUSE
ID CXCL3_MOUSE Reviewed; 100 AA.
AC Q6W5C0; Q3UNK9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=C-X-C motif chemokine 3;
DE AltName: Full=Dendritic cell inflammatory protein 1 {ECO:0000303|PubMed:14764687};
DE Flags: Precursor;
GN Name=Cxcl3 {ECO:0000312|MGI:MGI:3037818};
GN Synonyms=Dcip1 {ECO:0000312|EMBL:AAQ86937.1},
GN Gm1960 {ECO:0000312|MGI:MGI:3037818};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ86936.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=129/Sv X 129SvCp {ECO:0000312|EMBL:AAQ86937.1}, and
RC CBA/CaJ {ECO:0000312|EMBL:AAQ86936.1};
RC TISSUE=Dendritic cell {ECO:0000312|EMBL:AAQ86936.1};
RX PubMed=14764687; DOI=10.4049/jimmunol.172.4.2201;
RA Nolan K.F., Strong V., Soler D., Fairchild P.J., Cobbold S.P., Croxton R.,
RA Gonzalo J.-A., Rubio A., Wells M., Waldmann H.;
RT "IL-10-conditioned dendritic cells, decommissioned for recruitment of
RT adaptive immunity, elicit innate inflammatory gene products in response to
RT danger signals.";
RL J. Immunol. 172:2201-2209(2004).
RN [2] {ECO:0000312|EMBL:BAE29460.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE29460.1}, and
RC NOD {ECO:0000312|EMBL:BAE32520.1};
RC TISSUE=Bone marrow macrophage {ECO:0000312|EMBL:BAE29460.1}, and
RC Dendritic cell {ECO:0000312|EMBL:BAE32520.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI17015.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Ligand for CXCR2. Has chemotactic activity for neutrophils.
CC May play a role in inflammation and exert its effects on endothelial
CC cells in an autocrine fashion. {ECO:0000250|UniProtKB:Q10746,
CC ECO:0000269|PubMed:14764687}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q10746}.
CC -!- INDUCTION: By lipopolysaccharide. {ECO:0000269|PubMed:14764687}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE25738.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY311403; AAQ86936.1; -; mRNA.
DR EMBL; AY311404; AAQ86937.1; -; Genomic_DNA.
DR EMBL; AK144158; BAE25738.1; ALT_FRAME; mRNA.
DR EMBL; AK150314; BAE29460.1; -; mRNA.
DR EMBL; AK154334; BAE32520.1; -; mRNA.
DR EMBL; CH466617; EDL05303.1; -; Genomic_DNA.
DR EMBL; BC117014; AAI17015.1; -; mRNA.
DR EMBL; BC117016; AAI17017.1; -; mRNA.
DR CCDS; CCDS19417.1; -.
DR RefSeq; NP_976065.1; NM_203320.3.
DR AlphaFoldDB; Q6W5C0; -.
DR SMR; Q6W5C0; -.
DR STRING; 10090.ENSMUSP00000031326; -.
DR iPTMnet; Q6W5C0; -.
DR PhosphoSitePlus; Q6W5C0; -.
DR MaxQB; Q6W5C0; -.
DR PaxDb; Q6W5C0; -.
DR PRIDE; Q6W5C0; -.
DR ProteomicsDB; 279220; -.
DR DNASU; 330122; -.
DR Ensembl; ENSMUST00000031326; ENSMUSP00000031326; ENSMUSG00000029379.
DR GeneID; 330122; -.
DR KEGG; mmu:330122; -.
DR UCSC; uc008ybj.2; mouse.
DR CTD; 2921; -.
DR MGI; MGI:3037818; Cxcl3.
DR VEuPathDB; HostDB:ENSMUSG00000029379; -.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR GeneTree; ENSGT00940000155233; -.
DR HOGENOM; CLU_143902_3_1_1; -.
DR InParanoid; Q6W5C0; -.
DR OMA; PKFITNV; -.
DR OrthoDB; 1617719at2759; -.
DR PhylomeDB; Q6W5C0; -.
DR TreeFam; TF333433; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 330122; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q6W5C0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6W5C0; protein.
DR Bgee; ENSMUSG00000029379; Expressed in endothelial cell of lymphatic vessel and 24 other tissues.
DR Genevisible; Q6W5C0; MM.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0008009; F:chemokine activity; IDA:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR GO; GO:0030593; P:neutrophil chemotaxis; IDA:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000250|UniProtKB:Q10746"
FT CHAIN 32..100
FT /note="C-X-C motif chemokine 3"
FT /evidence="ECO:0000250|UniProtKB:Q10746"
FT /id="PRO_5000091636"
FT DISULFID 36..62
FT /evidence="ECO:0000250"
FT DISULFID 38..78
FT /evidence="ECO:0000250"
SQ SEQUENCE 100 AA; 10686 MW; 292AE7DA28DE525C CRC64;
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLN TLPRVDFETI QSLTVTPPGP
HCTQTEVIAT LKDGQEVCLN PQGPRLQIII KKILKSGKSS
