ID   CXCL5_RAT               Reviewed;         130 AA.
AC   P97885;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=C-X-C motif chemokine 5;
DE   AltName: Full=Cytokine LIX;
DE   AltName: Full=Small-inducible cytokine B5;
DE   Flags: Precursor;
GN   Name=Cxcl5; Synonyms=Scyb5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the recruitment of inflammatory cells by
CC       injured or infected tissue. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P42830}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; U90448; AAB61460.1; -; mRNA.
DR   RefSeq; NP_071550.1; NM_022214.1.
DR   AlphaFoldDB; P97885; -.
DR   SMR; P97885; -.
DR   STRING; 10116.ENSRNOP00000003823; -.
DR   PhosphoSitePlus; P97885; -.
DR   PaxDb; P97885; -.
DR   GeneID; 60665; -.
DR   KEGG; rno:60665; -.
DR   UCSC; RGD:708540; rat.
DR   CTD; 6372; -.
DR   RGD; 708540; Cxcl5.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   InParanoid; P97885; -.
DR   OrthoDB; 1556509at2759; -.
DR   PhylomeDB; P97885; -.
DR   Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P97885; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0008009; F:chemokine activity; IMP:RGD.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031100; P:animal organ regeneration; IMP:RGD.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IMP:RGD.
DR   GO; GO:0001776; P:leukocyte homeostasis; ISO:RGD.
DR   GO; GO:0030901; P:midbrain development; IEP:RGD.
DR   GO; GO:0042119; P:neutrophil activation; ISO:RGD.
DR   GO; GO:0030593; P:neutrophil chemotaxis; ISO:RGD.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:RGD.
DR   GO; GO:0032642; P:regulation of chemokine production; ISO:RGD.
DR   GO; GO:0070951; P:regulation of neutrophil mediated killing of gram-negative bacterium; ISO:RGD.
DR   GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000250"
FT   CHAIN           38..130
FT                   /note="C-X-C motif chemokine 5"
FT                   /id="PRO_0000005081"
FT   DISULFID        50..76
FT                   /evidence="ECO:0000250|UniProtKB:P42830"
FT   DISULFID        52..93
FT                   /evidence="ECO:0000250|UniProtKB:P42830"
SQ   SEQUENCE   130 AA;  14263 MW;  C00F6B3605524F4E CRC64;
     MSFQLRSSAR IPSRSCSSFT LLAFLLLFTL PQHRAQAAPF SAMVATELRC VCLTLAPRIN
     PKMIANLEVI PAGPHCPKVE VIAKLKNQKD NVCLDPQAPL IKKVIQKILG SENKKTKRNA
     LALVRSASTQ