ID   CXCL6_HORSE             Reviewed;         113 AA.
AC   Q8MIN2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=C-X-C motif chemokine 6;
DE   AltName: Full=Granulocyte chemotactic protein 2;
DE            Short=GCP-2;
DE   AltName: Full=Small-inducible cytokine B6;
DE   Flags: Precursor;
GN   Name=CXCL6; Synonyms=GCP2, SCYB6;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic for neutrophil granulocytes. Signals through
CC       binding and activation of its receptors (CXCR1 and CXCR2). In addition
CC       to its chemotactic and angiogenic properties, it has strong
CC       antibacterial activity against Gram-positive and Gram-negative bacteria
CC       (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY114351; AAM76679.1; -; mRNA.
DR   RefSeq; NP_001075355.2; NM_001081886.2.
DR   AlphaFoldDB; Q8MIN2; -.
DR   SMR; Q8MIN2; -.
DR   STRING; 9796.ENSECAP00000010532; -.
DR   PaxDb; Q8MIN2; -.
DR   GeneID; 100033988; -.
DR   KEGG; ecb:100033988; -.
DR   CTD; 6372; -.
DR   InParanoid; Q8MIN2; -.
DR   OrthoDB; 1556509at2759; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Chemotaxis; Cytokine; Disulfide bond;
KW   Heparin-binding; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000250"
FT   CHAIN           37..113
FT                   /note="C-X-C motif chemokine 6"
FT                   /id="PRO_0000005083"
FT   DISULFID        48..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  11897 MW;  ADF0DB2E0309B475 CRC64;
     MSLLPSRAAR VPGPSSSLCA LLALLLLTPP GPLVSAGPVA AAVRELRCMC LTVTPGIHPK
     MISSLQVFAV GPQCSKVEVV PTLKNKKEVC LDPEAPLIKK FIQKTLDSGN KKN