ID   CXCL7_PIG               Reviewed;         119 AA.
AC   P43030;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Platelet basic protein;
DE            Short=PBP;
DE   AltName: Full=C-X-C motif chemokine 7;
DE   AltName: Full=Small-inducible cytokine B7;
DE   Flags: Precursor;
GN   Name=PPBP; Synonyms=CXCL7, SCYB7;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-119, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Platelet;
RX   PubMed=7513641; DOI=10.1111/j.1432-1033.1994.tb18784.x;
RA   Power C.A., Proudfoot A.E.I., Magnenat E., Bacon K.B., Wells T.N.C.;
RT   "Molecular cloning and characterisation of a neutrophil chemotactic protein
RT   from porcine platelets.";
RL   Eur. J. Biochem. 221:713-719(1994).
CC   -!- FUNCTION: Chemoattractant factor for neutrophils.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=8597.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:7513641};
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; X77935; CAA54907.1; -; mRNA.
DR   PIR; S43460; S42881.
DR   RefSeq; NP_999027.1; NM_213862.2.
DR   RefSeq; XP_003126210.1; XM_003126162.3.
DR   AlphaFoldDB; P43030; -.
DR   SMR; P43030; -.
DR   STRING; 9823.ENSSSCP00000000259; -.
DR   PaxDb; P43030; -.
DR   Ensembl; ENSSSCT00000041161; ENSSSCP00000045908; ENSSSCG00000037579.
DR   Ensembl; ENSSSCT00005065283; ENSSSCP00005040340; ENSSSCG00005040808.
DR   Ensembl; ENSSSCT00015038321; ENSSSCP00015015209; ENSSSCG00015028911.
DR   Ensembl; ENSSSCT00030051075; ENSSSCP00030023244; ENSSSCG00030036728.
DR   Ensembl; ENSSSCT00055061081; ENSSSCP00055048969; ENSSSCG00055030644.
DR   Ensembl; ENSSSCT00060054732; ENSSSCP00060023346; ENSSSCG00060040430.
DR   Ensembl; ENSSSCT00070012108; ENSSSCP00070009970; ENSSSCG00070006337.
DR   GeneID; 396870; -.
DR   KEGG; ssc:396870; -.
DR   CTD; 5473; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   GeneTree; ENSGT00940000162559; -.
DR   HOGENOM; CLU_143902_1_1_1; -.
DR   InParanoid; P43030; -.
DR   OrthoDB; 1617719at2759; -.
DR   TreeFam; TF333433; -.
DR   Reactome; R-SSC-114608; Platelet degranulation.
DR   Reactome; R-SSC-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-SSC-418594; G alpha (i) signalling events.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008227; Chromosome 8.
DR   Proteomes; UP000314985; Chromosome 8.
DR   Bgee; ENSSSCG00000037579; Expressed in blood and 40 other tissues.
DR   ExpressionAtlas; P43030; baseline and differential.
DR   Genevisible; P43030; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Growth factor; Mitogen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000305"
FT   PROPEP          34..39
FT                   /evidence="ECO:0000269|PubMed:7513641"
FT                   /id="PRO_0000005097"
FT   CHAIN           40..119
FT                   /note="Platelet basic protein"
FT                   /id="PRO_0000005098"
FT   DISULFID        54..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..96
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   119 AA;  12615 MW;  79E1D409CDD06B32 CRC64;
     MSLRLGAISS CTTSSPFPVL QVLLPLSLLL TTLVPATMGA AKIEGRMAHV ELRCLCLNTV
     SGIHPSNIQS LEVIRAGAHC AKVEVIATLK NDKKICLDPE APRIKKIVQK IMEDGGSAA