ID   CXCL9_BOVIN             Reviewed;         125 AA.
AC   A9QWP9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=C-X-C motif chemokine 9;
DE   AltName: Full=Small-inducible cytokine B9;
DE   Flags: Precursor;
GN   Name=CXCL9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG   U.S. Veterinary Immune Reagent Network;
RA   Hudgens T., Tompkins D., Baldwin C.L.;
RT   "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that affects the growth, movement, or activation
CC       state of cells that participate in immune and inflammatory response.
CC       Chemotactic for activated T-cells. Binds to CXCR3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; EU276061; ABX72059.1; -; mRNA.
DR   RefSeq; NP_001106643.1; NM_001113172.1.
DR   AlphaFoldDB; A9QWP9; -.
DR   SMR; A9QWP9; -.
DR   STRING; 9913.ENSBTAP00000002257; -.
DR   PaxDb; A9QWP9; -.
DR   Ensembl; ENSBTAT00000075648; ENSBTAP00000057632; ENSBTAG00000050852.
DR   GeneID; 513990; -.
DR   KEGG; bta:513990; -.
DR   CTD; 4283; -.
DR   VEuPathDB; HostDB:ENSBTAG00000050852; -.
DR   VGNC; VGNC:27854; CXCL9.
DR   eggNOG; ENOG502TDRN; Eukaryota.
DR   GeneTree; ENSGT00940000161751; -.
DR   HOGENOM; CLU_143902_2_2_1; -.
DR   InParanoid; A9QWP9; -.
DR   OMA; CLNPDST; -.
DR   OrthoDB; 1548456at2759; -.
DR   TreeFam; TF333433; -.
DR   Reactome; R-BTA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-BTA-418594; G alpha (i) signalling events.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000050852; Expressed in abdominal lymph node and 92 other tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Inflammatory response; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..125
FT                   /note="C-X-C motif chemokine 9"
FT                   /id="PRO_0000326169"
FT   REGION          91..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..125
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        30..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  14106 MW;  998ACC440262FE3A CRC64;
     MKKSAPLFLG IIFLTLTGVQ GVPAIRNGRC SCINTSQGMI HPKSLKDLKQ FAPSPSCEKT
     EIIATMKNGN EACLNPDLPE VKELIKEWEK QVNQKKKQRK GKKYKKTKKV PKVKRSQRPS
     QKKTT