CXCL9_HUMAN
ID CXCL9_HUMAN Reviewed; 125 AA.
AC Q07325; Q503B4;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=C-X-C motif chemokine 9;
DE AltName: Full=Gamma-interferon-induced monokine;
DE AltName: Full=Monokine induced by interferon-gamma;
DE Short=HuMIG;
DE Short=MIG;
DE AltName: Full=Small-inducible cytokine B9;
DE Flags: Precursor;
GN Name=CXCL9; Synonyms=CMK, MIG, SCYB9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Monocyte;
RX PubMed=8476424; DOI=10.1006/bbrc.1993.1403;
RA Farber J.M.;
RT "HuMig: a new human member of the chemokine family of cytokines.";
RL Biochem. Biophys. Res. Commun. 192:223-230(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 23-28.
RC TISSUE=Keratinocyte;
RX PubMed=10233762; DOI=10.1046/j.1523-1747.1999.00581.x;
RA Tensen C.P., Flier J., van der Raaij-Helmer E.M.H.,
RA Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J.,
RA Boorsma D.M., Willemze R.;
RT "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for
RT the IP-10/Mig receptor (CXCR3).";
RL J. Invest. Dermatol. 112:716-722(1999).
CC -!- FUNCTION: Cytokine that affects the growth, movement, or activation
CC state of cells that participate in immune and inflammatory response.
CC Chemotactic for activated T-cells. Binds to CXCR3.
CC -!- INTERACTION:
CC Q07325; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-3911467, EBI-19125216;
CC Q07325; Q13520: AQP6; NbExp=3; IntAct=EBI-3911467, EBI-13059134;
CC Q07325; Q9UN42: ATP1B4; NbExp=3; IntAct=EBI-3911467, EBI-12894731;
CC Q07325; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-3911467, EBI-11532900;
CC Q07325; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-3911467, EBI-17953245;
CC Q07325; O00585: CCL21; NbExp=2; IntAct=EBI-3911467, EBI-953695;
CC Q07325; Q9Y258: CCL26; NbExp=2; IntAct=EBI-3911467, EBI-7783416;
CC Q07325; P13501: CCL5; NbExp=2; IntAct=EBI-3911467, EBI-2848366;
CC Q07325; P20138: CD33; NbExp=3; IntAct=EBI-3911467, EBI-3906571;
CC Q07325; Q9H9P2: CHODL; NbExp=3; IntAct=EBI-3911467, EBI-17447707;
CC Q07325; P57739: CLDN2; NbExp=3; IntAct=EBI-3911467, EBI-751440;
CC Q07325; O00501: CLDN5; NbExp=3; IntAct=EBI-3911467, EBI-18400628;
CC Q07325; O95471: CLDN7; NbExp=3; IntAct=EBI-3911467, EBI-740744;
CC Q07325; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-3911467, EBI-11977093;
CC Q07325; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-3911467, EBI-11749983;
CC Q07325; Q9ULY5: CLEC4E; NbExp=3; IntAct=EBI-3911467, EBI-12807010;
CC Q07325; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-3911467, EBI-11989440;
CC Q07325; P02778: CXCL10; NbExp=2; IntAct=EBI-3911467, EBI-7815386;
CC Q07325; P48061: CXCL12; NbExp=2; IntAct=EBI-3911467, EBI-3913254;
CC Q07325; O95715: CXCL14; NbExp=2; IntAct=EBI-3911467, EBI-2798068;
CC Q07325; P27487: DPP4; NbExp=2; IntAct=EBI-3911467, EBI-2871277;
CC Q07325; Q6UW88-2: EPGN; NbExp=3; IntAct=EBI-3911467, EBI-17468158;
CC Q07325; O14944: EREG; NbExp=3; IntAct=EBI-3911467, EBI-17272224;
CC Q07325; P12318-2: FCGR2A; NbExp=3; IntAct=EBI-3911467, EBI-17187481;
CC Q07325; O15552: FFAR2; NbExp=3; IntAct=EBI-3911467, EBI-2833872;
CC Q07325; Q96LL3: FIMP; NbExp=3; IntAct=EBI-3911467, EBI-12887376;
CC Q07325; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-3911467, EBI-12142257;
CC Q07325; Q11130: FUT7; NbExp=3; IntAct=EBI-3911467, EBI-12817667;
CC Q07325; P08034: GJB1; NbExp=3; IntAct=EBI-3911467, EBI-17565645;
CC Q07325; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-3911467, EBI-3917143;
CC Q07325; O15529: GPR42; NbExp=3; IntAct=EBI-3911467, EBI-18076404;
CC Q07325; P38484: IFNGR2; NbExp=3; IntAct=EBI-3911467, EBI-3905457;
CC Q07325; Q9NQX7-3: ITM2C; NbExp=3; IntAct=EBI-3911467, EBI-12811565;
CC Q07325; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-3911467, EBI-749265;
CC Q07325; P43628: KIR2DL3; NbExp=3; IntAct=EBI-3911467, EBI-8632435;
CC Q07325; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-3911467, EBI-10173166;
CC Q07325; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-3911467, EBI-17490413;
CC Q07325; Q8N386: LRRC25; NbExp=3; IntAct=EBI-3911467, EBI-11304917;
CC Q07325; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-3911467, EBI-10264855;
CC Q07325; Q95460-2: MR1; NbExp=3; IntAct=EBI-3911467, EBI-12201447;
CC Q07325; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-3911467, EBI-3923617;
CC Q07325; P15941-11: MUC1; NbExp=3; IntAct=EBI-3911467, EBI-17263240;
CC Q07325; O14524-2: NEMP1; NbExp=3; IntAct=EBI-3911467, EBI-10969203;
CC Q07325; P02776: PF4; NbExp=3; IntAct=EBI-3911467, EBI-2565740;
CC Q07325; P02775: PPBP; NbExp=2; IntAct=EBI-3911467, EBI-718973;
CC Q07325; P54829: PTPN5; NbExp=3; IntAct=EBI-3911467, EBI-1220572;
CC Q07325; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-3911467, EBI-15853497;
CC Q07325; P11686: SFTPC; NbExp=7; IntAct=EBI-3911467, EBI-10197617;
CC Q07325; Q14973: SLC10A1; NbExp=3; IntAct=EBI-3911467, EBI-3923031;
CC Q07325; Q9NY26: SLC39A1; NbExp=3; IntAct=EBI-3911467, EBI-726491;
CC Q07325; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-3911467, EBI-17280858;
CC Q07325; Q96L08: SUSD3; NbExp=3; IntAct=EBI-3911467, EBI-18194029;
CC Q07325; Q8N205: SYNE4; NbExp=3; IntAct=EBI-3911467, EBI-7131783;
CC Q07325; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-3911467, EBI-13351685;
CC Q07325; Q9Y3A6: TMED5; NbExp=3; IntAct=EBI-3911467, EBI-7560959;
CC Q07325; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3911467, EBI-2821497;
CC Q07325; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-3911467, EBI-8642211;
CC Q07325; Q96Q45-2: TMEM237; NbExp=5; IntAct=EBI-3911467, EBI-10982110;
CC Q07325; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-3911467, EBI-12345267;
CC Q07325; O43557: TNFSF14; NbExp=3; IntAct=EBI-3911467, EBI-524131;
CC Q07325; P32971: TNFSF8; NbExp=3; IntAct=EBI-3911467, EBI-13076860;
CC Q07325; Q8WUV1: TSPAN18; NbExp=3; IntAct=EBI-3911467, EBI-17670824;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- INDUCTION: By IFNG/IFN-gamma. The induction is enhanced by TNF in
CC dermal fibroblasts and vein endothelial cells.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CXCL9 entry;
CC URL="https://en.wikipedia.org/wiki/CXCL9";
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DR EMBL; X72755; CAA51284.1; -; mRNA.
DR EMBL; BC063122; AAH63122.1; -; mRNA.
DR EMBL; BC095396; AAH95396.1; -; mRNA.
DR CCDS; CCDS34014.1; -.
DR PIR; JN0470; JN0470.
DR RefSeq; NP_002407.1; NM_002416.2.
DR AlphaFoldDB; Q07325; -.
DR BioGRID; 110429; 77.
DR DIP; DIP-5892N; -.
DR IntAct; Q07325; 72.
DR MINT; Q07325; -.
DR STRING; 9606.ENSP00000354901; -.
DR iPTMnet; Q07325; -.
DR PhosphoSitePlus; Q07325; -.
DR BioMuta; CXCL9; -.
DR DMDM; 585487; -.
DR EPD; Q07325; -.
DR MassIVE; Q07325; -.
DR PaxDb; Q07325; -.
DR PeptideAtlas; Q07325; -.
DR PRIDE; Q07325; -.
DR ProteomicsDB; 58509; -.
DR ABCD; Q07325; 4 sequenced antibodies.
DR Antibodypedia; 24750; 650 antibodies from 37 providers.
DR CPTC; Q07325; 2 antibodies.
DR DNASU; 4283; -.
DR Ensembl; ENST00000264888.6; ENSP00000354901.4; ENSG00000138755.6.
DR GeneID; 4283; -.
DR KEGG; hsa:4283; -.
DR MANE-Select; ENST00000264888.6; ENSP00000354901.4; NM_002416.3; NP_002407.1.
DR UCSC; uc003hjh.2; human.
DR CTD; 4283; -.
DR DisGeNET; 4283; -.
DR GeneCards; CXCL9; -.
DR HGNC; HGNC:7098; CXCL9.
DR HPA; ENSG00000138755; Tissue enriched (lymphoid).
DR MIM; 601704; gene.
DR neXtProt; NX_Q07325; -.
DR OpenTargets; ENSG00000138755; -.
DR PharmGKB; PA35495; -.
DR VEuPathDB; HostDB:ENSG00000138755; -.
DR eggNOG; ENOG502TDRN; Eukaryota.
DR GeneTree; ENSGT00940000161751; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR InParanoid; Q07325; -.
DR OMA; CLNPDST; -.
DR OrthoDB; 1548456at2759; -.
DR PhylomeDB; Q07325; -.
DR TreeFam; TF333433; -.
DR PathwayCommons; Q07325; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q07325; -.
DR SIGNOR; Q07325; -.
DR BioGRID-ORCS; 4283; 6 hits in 1074 CRISPR screens.
DR ChiTaRS; CXCL9; human.
DR GeneWiki; CXCL9; -.
DR GenomeRNAi; 4283; -.
DR Pharos; Q07325; Tbio.
DR PRO; PR:Q07325; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q07325; protein.
DR Bgee; ENSG00000138755; Expressed in vermiform appendix and 131 other tissues.
DR Genevisible; Q07325; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IDA:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IDA:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
DR GO; GO:0006952; P:defense response; TAS:ProtInc.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 1: Evidence at protein level;
KW Cytokine; Direct protein sequencing; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:10233762"
FT CHAIN 23..125
FT /note="C-X-C motif chemokine 9"
FT /id="PRO_0000005099"
FT REGION 93..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..125
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 31..58
FT /evidence="ECO:0000250"
FT DISULFID 33..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 125 AA; 14019 MW; 630F8FCFCE125709 CRC64;
MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK
IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR
QKKTT
