CXCL9_MOUSE
ID CXCL9_MOUSE Reviewed; 126 AA.
AC P18340; Q8C9J0; Q99J60;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=C-X-C motif chemokine 9;
DE AltName: Full=Gamma-interferon-induced monokine;
DE AltName: Full=Monokine induced by interferon-gamma;
DE Short=MIG;
DE Short=MuMIG;
DE AltName: Full=Protein m119;
DE AltName: Full=Small-inducible cytokine B9;
DE Flags: Precursor;
GN Name=Cxcl9; Synonyms=Mig, Scyb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2115167; DOI=10.1073/pnas.87.14.5238;
RA Farber J.M.;
RT "A macrophage mRNA selectively induced by gamma-interferon encodes a member
RT of the platelet factor 4 family of cytokines.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:5238-5242(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a cytokine that affects the growth, movement, or
CC activation state of cells that participate in immune and inflammatory
CC response.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- INDUCTION: By interferon gamma.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; M34815; AAA39706.1; -; mRNA.
DR EMBL; AK042017; BAC31132.1; -; mRNA.
DR EMBL; AK156012; BAE33544.1; -; mRNA.
DR EMBL; AK156029; BAE33552.1; -; mRNA.
DR EMBL; AK156453; BAE33718.1; -; mRNA.
DR EMBL; AK157118; BAE33967.1; -; mRNA.
DR EMBL; CT010194; CAJ18402.1; -; mRNA.
DR EMBL; AC122365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466617; EDL05257.1; -; Genomic_DNA.
DR EMBL; BC003343; AAH03343.1; -; mRNA.
DR CCDS; CCDS39152.1; -.
DR PIR; A35766; A35766.
DR RefSeq; NP_032625.2; NM_008599.4.
DR AlphaFoldDB; P18340; -.
DR SMR; P18340; -.
DR STRING; 10090.ENSMUSP00000108716; -.
DR GlyGen; P18340; 1 site.
DR iPTMnet; P18340; -.
DR PhosphoSitePlus; P18340; -.
DR PaxDb; P18340; -.
DR PRIDE; P18340; -.
DR ProteomicsDB; 283987; -.
DR Antibodypedia; 24750; 650 antibodies from 37 providers.
DR DNASU; 17329; -.
DR Ensembl; ENSMUST00000113093; ENSMUSP00000108716; ENSMUSG00000029417.
DR GeneID; 17329; -.
DR KEGG; mmu:17329; -.
DR UCSC; uc008ycv.2; mouse.
DR CTD; 4283; -.
DR MGI; MGI:1352449; Cxcl9.
DR VEuPathDB; HostDB:ENSMUSG00000029417; -.
DR eggNOG; ENOG502TDRN; Eukaryota.
DR GeneTree; ENSGT00940000161751; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR InParanoid; P18340; -.
DR OMA; CLNPDST; -.
DR OrthoDB; 1548456at2759; -.
DR PhylomeDB; P18340; -.
DR TreeFam; TF333433; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 17329; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Cxcl9; mouse.
DR PRO; PR:P18340; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P18340; protein.
DR Bgee; ENSMUSG00000029417; Expressed in subcutaneous adipose tissue and 73 other tissues.
DR Genevisible; P18340; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IDA:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IMP:MGI.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IMP:MGI.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT CHAIN 22..126
FT /note="C-X-C motif chemokine 9"
FT /id="PRO_0000005100"
FT REGION 91..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..126
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 30..57
FT /evidence="ECO:0000250"
FT DISULFID 32..73
FT /evidence="ECO:0000250"
FT CONFLICT 40
FT /note="I -> V (in Ref. 6; AAH03343)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="S -> N (in Ref. 1; AAA39706 and 6; AAH03343)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 126 AA; 14444 MW; CB682C0E0D5D0322 CRC64;
MKSAVLFLLG IIFLEQCGVR GTLVIRNARC SCISTSRGTI HYKSLKDLKQ FAPSPNCNKT
EIIATLKNGD QTCLDPDSAN VKKLMKEWEK KISQKKKQKR GKKHQKNMKN RKPKTPQSRR
RSRKTT
