CXCR1_MOUSE
ID CXCR1_MOUSE Reviewed; 351 AA.
AC Q810W6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=C-X-C chemokine receptor type 1;
DE Short=CXC-R1;
DE Short=CXCR-1;
DE AltName: Full=High affinity interleukin-8 receptor A;
DE Short=IL-8R A;
DE AltName: CD_antigen=CD181;
GN Name=Cxcr1; Synonyms=Il8ra;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Xiong S.S., Hickey G.E., Humphrey J.E.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=15967374; DOI=10.1016/j.cyto.2005.02.005;
RA Fu W., Zhang Y., Zhang J., Chen W.F.;
RT "Cloning and characterization of mouse homolog of the CXC chemokine
RT receptor CXCR1.";
RL Cytokine 31:9-17(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16084593; DOI=10.1016/j.molimm.2005.06.043;
RA Moepps B., Nuesseler E., Braun M., Gierschik P.;
RT "A homolog of the human chemokine receptor CXCR1 is expressed in the
RT mouse.";
RL Mol. Immunol. 43:897-914(2006).
RN [4]
RP PROTEIN SEQUENCE OF 340-351, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils
CC chemotactic factor. Binding of IL-8 to the receptor causes activation
CC of neutrophils. This response is mediated via a G-protein that
CC activates a phosphatidylinositol-calcium second messenger system.
CC {ECO:0000250|UniProtKB:P25024}.
CC -!- SUBUNIT: Interacts with IL8. Interacts with GNAI2.
CC {ECO:0000250|UniProtKB:P25024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY227797; AAO72727.1; -; mRNA.
DR EMBL; AY749637; AAU87365.1; -; mRNA.
DR EMBL; AY390263; AAQ84305.1; -; mRNA.
DR CCDS; CCDS15041.1; -.
DR RefSeq; NP_839972.1; NM_178241.4.
DR RefSeq; XP_011236803.1; XM_011238501.2.
DR RefSeq; XP_011236805.1; XM_011238503.2.
DR AlphaFoldDB; Q810W6; -.
DR SMR; Q810W6; -.
DR STRING; 10090.ENSMUSP00000139555; -.
DR GlyGen; Q810W6; 1 site.
DR PhosphoSitePlus; Q810W6; -.
DR EPD; Q810W6; -.
DR PaxDb; Q810W6; -.
DR PRIDE; Q810W6; -.
DR Antibodypedia; 4267; 629 antibodies from 46 providers.
DR DNASU; 227288; -.
DR Ensembl; ENSMUST00000053389; ENSMUSP00000049714; ENSMUSG00000048480.
DR Ensembl; ENSMUST00000190313; ENSMUSP00000139555; ENSMUSG00000048480.
DR GeneID; 227288; -.
DR KEGG; mmu:227288; -.
DR UCSC; uc007blm.1; mouse.
DR CTD; 3577; -.
DR MGI; MGI:2448715; Cxcr1.
DR VEuPathDB; HostDB:ENSMUSG00000048480; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244848; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q810W6; -.
DR OMA; QSICYEN; -.
DR OrthoDB; 865441at2759; -.
DR PhylomeDB; Q810W6; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 227288; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Cxcr2; mouse.
DR PRO; PR:Q810W6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q810W6; protein.
DR Bgee; ENSMUSG00000048480; Expressed in granulocyte and 5 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019959; F:interleukin-8 binding; ISO:MGI.
DR GO; GO:0004918; F:interleukin-8 receptor activity; ISO:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0031623; P:receptor internalization; ISO:MGI.
DR InterPro; IPR000174; Chemokine_CXCR_1/2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00427; INTRLEUKIN8R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chemotaxis; Direct protein sequencing; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..351
FT /note="C-X-C chemokine receptor type 1"
FT /id="PRO_0000277473"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..71
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..138
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..313
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 115..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 351 AA; 40032 MW; E4B73073A72B8B13 CRC64;
MAEAEYFIWT NPEGDFEKEF GNITGMLPTG DYFIPCKRVP ITNRQALVVF YALVSLLSLL
GNSLVMLVIL YRRRTRSVMD VYVLNLAIAD LLFSLTLPFL AVSKLKGWIF GTPLCKMVSL
LKEFNFFSGI LLLACISVDR YLAIVHATRT LARKRYLVKF VCVGIWGLSL ILSLPFAIFR
QAYKPFRSGT VCYEVLGEAT TDFRMTLRGL SHIFGFLLPL LTMLVCYGLT LRMLFKTHMR
QKHRAMGVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIED TCERRNDIDQ ALYITEILGF
SHSCLNPIIY AFVGQNFRHE FLKILANHGL VRKEVLTHRR VAFHTSLTAI Y
