CXCR2_RAT
ID CXCR2_RAT Reviewed; 359 AA.
AC P35407;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=C-X-C chemokine receptor type 2;
DE Short=CXC-R2;
DE Short=CXCR-2;
DE AltName: Full=GRO/MGSA receptor;
DE AltName: Full=High affinity interleukin-8 receptor B;
DE Short=IL-8R B;
DE AltName: CD_antigen=CD182;
GN Name=Cxcr2; Synonyms=Il8rb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Lung;
RX PubMed=9218548; DOI=10.1016/s0005-2736(97)00065-5;
RA Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.;
RT "Molecular cloning and characterization of a cDNA encoding the rat
RT interleukin-8 receptor.";
RL Biochim. Biophys. Acta 1326:171-177(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar; TISSUE=Liver;
RA Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.;
RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar; TISSUE=Lung, and Spleen;
RX PubMed=8955112; DOI=10.1074/jbc.271.51.32770;
RA Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L.,
RA Harrison J.K.;
RT "Identification of two rat genes orthologous to the human interleukin-8
RT receptors.";
RL J. Biol. Chem. 271:32770-32776(1996).
CC -!- FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil
CC chemotactic factor. Binding of IL-8 to the receptor causes activation
CC of neutrophils. This response is mediated via a G-protein that
CC activates a phosphatidylinositol-calcium second messenger system. Binds
CC to IL-8 with high affinity. Also binds with high affinity to CXCL3,
CC GRO/MGSA and NAP-2. {ECO:0000250|UniProtKB:P25025}.
CC -!- SUBUNIT: Interacts with IL8. Interacts with GNAI2.
CC {ECO:0000250|UniProtKB:P25025}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated upon ligand binding; which is required for
CC desensitization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X77797; CAA54824.1; -; mRNA.
DR EMBL; D63584; BAA09797.1; -; Genomic_DNA.
DR EMBL; U70988; AAC52961.1; -; Genomic_DNA.
DR PIR; S42096; S42096.
DR RefSeq; NP_058879.1; NM_017183.1.
DR RefSeq; XP_008765435.1; XM_008767213.2.
DR AlphaFoldDB; P35407; -.
DR SMR; P35407; -.
DR BioGRID; 248037; 3.
DR IntAct; P35407; 1.
DR MINT; P35407; -.
DR STRING; 10116.ENSRNOP00000019109; -.
DR GlyGen; P35407; 4 sites.
DR PhosphoSitePlus; P35407; -.
DR PaxDb; P35407; -.
DR PRIDE; P35407; -.
DR Ensembl; ENSRNOT00000101059; ENSRNOP00000093296; ENSRNOG00000063618.
DR GeneID; 29385; -.
DR KEGG; rno:29385; -.
DR UCSC; RGD:2906; rat.
DR CTD; 3579; -.
DR RGD; 2906; Cxcr2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244848; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P35407; -.
DR OMA; FIFREAY; -.
DR OrthoDB; 865441at2759; -.
DR PhylomeDB; P35407; -.
DR TreeFam; TF330966; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR PRO; PR:P35407; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000014269; Expressed in esophagus and 10 other tissues.
DR ExpressionAtlas; P35407; baseline and differential.
DR Genevisible; P35407; RN.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042629; C:mast cell granule; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; ISO:RGD.
DR GO; GO:0004950; F:chemokine receptor activity; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:RGD.
DR GO; GO:0019959; F:interleukin-8 binding; ISO:RGD.
DR GO; GO:0004918; F:interleukin-8 receptor activity; ISO:RGD.
DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IMP:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
DR GO; GO:0006968; P:cellular defense response; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0038112; P:interleukin-8-mediated signaling pathway; ISO:RGD.
DR GO; GO:0072173; P:metanephric tubule morphogenesis; IMP:RGD.
DR GO; GO:0030901; P:midbrain development; IEP:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR GO; GO:0033030; P:negative regulation of neutrophil apoptotic process; IMP:RGD.
DR GO; GO:0042119; P:neutrophil activation; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IMP:RGD.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
DR GO; GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IMP:RGD.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IMP:RGD.
DR GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
DR GO; GO:0031623; P:receptor internalization; ISO:RGD.
DR InterPro; IPR000057; Chemokine_CXCR2.
DR InterPro; IPR000174; Chemokine_CXCR_1/2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00427; INTRLEUKIN8R.
DR PRINTS; PR00573; INTRLEUKN8BR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="C-X-C chemokine receptor type 2"
FT /id="PRO_0000069342"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..74
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..182
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 118..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 359 AA; 40532 MW; EF547326A074ABDD CRC64;
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV VVIYVLVTLL
SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL PVWAASKVNG WIFGSFLCKV
FSFLQEITFY SSVLLLACIS MDRYLAIVHA TSTLIQKRHL VKFVCITMWF LSLVLSLPIF
ILRTTVKANP STVVCYENIG NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA
HMGQKHRAMR VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS SSANTSTTL
