CXCR5_HUMAN
ID CXCR5_HUMAN Reviewed; 372 AA.
AC P32302; Q14811;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 194.
DE RecName: Full=C-X-C chemokine receptor type 5;
DE Short=CXC-R5;
DE Short=CXCR-5;
DE AltName: Full=Burkitt lymphoma receptor 1;
DE AltName: Full=Monocyte-derived receptor 15;
DE Short=MDR-15;
DE AltName: CD_antigen=CD185;
GN Name=CXCR5; Synonyms=BLR1, MDR15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
RC TISSUE=Lymphocyte;
RX PubMed=1425907; DOI=10.1002/eji.1830221107;
RA Dobner T., Wolf I., Emrich T., Lipp M.;
RT "Differentiation-specific expression of a novel G protein-coupled receptor
RT from Burkitt's lymphoma.";
RL Eur. J. Immunol. 22:2795-2799(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC TISSUE=Blood;
RX PubMed=7639692; DOI=10.1042/bj3090773;
RA Barella L., Loetscher M., Tobler A., Baggiolini M., Moser B.;
RT "Sequence variation of a novel heptahelical leucocyte receptor through
RT alternative transcript formation.";
RL Biochem. J. 309:773-779(1995).
RN [3]
RP LIGAND-BINDING.
RX PubMed=9463416; DOI=10.1084/jem.187.4.655;
RA Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M.,
RA Moser B.;
RT "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid
RT tissues, selectively attracts B lymphocytes via BLR1/CXCR5.";
RL J. Exp. Med. 187:655-660(1998).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] LYS-34.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Cytokine receptor that binds to B-lymphocyte chemoattractant
CC (BLC). Involved in B-cell migration into B-cell follicles of spleen and
CC Peyer patches but not into those of mesenteric or peripheral lymph
CC nodes. May have a regulatory function in Burkitt lymphoma (BL)
CC lymphomagenesis and/or B-cell differentiation.
CC -!- INTERACTION:
CC P32302; P61073: CXCR4; NbExp=3; IntAct=EBI-2835269, EBI-489411;
CC P32302; Q14344: GNA13; NbExp=9; IntAct=EBI-2835269, EBI-465387;
CC P32302; P04899: GNAI2; NbExp=5; IntAct=EBI-2835269, EBI-353997;
CC P32302; P16520: GNB3; NbExp=3; IntAct=EBI-2835269, EBI-2880663;
CC P32302; Q9UK08: GNG8; NbExp=3; IntAct=EBI-2835269, EBI-9074207;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P32302-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P32302-2; Sequence=VSP_001892;
CC -!- TISSUE SPECIFICITY: Expression in mature B-cells and Burkitt lymphoma
CC cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry;
CC URL="https://en.wikipedia.org/wiki/CXC_chemokine_receptors";
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DR EMBL; X68149; CAA48252.1; -; mRNA.
DR EMBL; X68829; CAA48723.1; -; mRNA.
DR CCDS; CCDS8402.1; -. [P32302-1]
DR PIR; S26667; S26667.
DR RefSeq; NP_001707.1; NM_001716.4. [P32302-1]
DR RefSeq; NP_116743.1; NM_032966.2. [P32302-2]
DR AlphaFoldDB; P32302; -.
DR SMR; P32302; -.
DR BioGRID; 107112; 6.
DR DIP; DIP-5834N; -.
DR IntAct; P32302; 8.
DR MINT; P32302; -.
DR STRING; 9606.ENSP00000292174; -.
DR BindingDB; P32302; -.
DR ChEMBL; CHEMBL1075315; -.
DR GuidetoPHARMACOLOGY; 72; -.
DR GlyGen; P32302; 3 sites.
DR iPTMnet; P32302; -.
DR PhosphoSitePlus; P32302; -.
DR BioMuta; CXCR5; -.
DR DMDM; 416718; -.
DR MassIVE; P32302; -.
DR PaxDb; P32302; -.
DR PeptideAtlas; P32302; -.
DR PRIDE; P32302; -.
DR ProteomicsDB; 54865; -. [P32302-1]
DR ProteomicsDB; 54866; -. [P32302-2]
DR Antibodypedia; 18705; 649 antibodies from 41 providers.
DR DNASU; 643; -.
DR Ensembl; ENST00000292174.5; ENSP00000292174.4; ENSG00000160683.5. [P32302-1]
DR GeneID; 643; -.
DR KEGG; hsa:643; -.
DR MANE-Select; ENST00000292174.5; ENSP00000292174.4; NM_001716.5; NP_001707.1.
DR UCSC; uc001pue.5; human. [P32302-1]
DR CTD; 643; -.
DR DisGeNET; 643; -.
DR GeneCards; CXCR5; -.
DR HGNC; HGNC:1060; CXCR5.
DR HPA; ENSG00000160683; Group enriched (bone marrow, intestine, lymphoid tissue).
DR MIM; 601613; gene.
DR neXtProt; NX_P32302; -.
DR OpenTargets; ENSG00000160683; -.
DR PharmGKB; PA162383046; -.
DR VEuPathDB; HostDB:ENSG00000160683; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244848; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P32302; -.
DR OMA; IGFTHCC; -.
DR PhylomeDB; P32302; -.
DR TreeFam; TF330966; -.
DR PathwayCommons; P32302; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P32302; -.
DR BioGRID-ORCS; 643; 14 hits in 1065 CRISPR screens.
DR ChiTaRS; CXCR5; human.
DR GeneWiki; CXCR5; -.
DR GenomeRNAi; 643; -.
DR Pharos; P32302; Tchem.
DR PRO; PR:P32302; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P32302; protein.
DR Bgee; ENSG00000160683; Expressed in granulocyte and 98 other tissues.
DR ExpressionAtlas; P32302; baseline and differential.
DR Genevisible; P32302; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0030595; P:leukocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR001053; Chemokine_CXCR5.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00564; CXCCHMKINER5.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; B-cell activation; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..372
FT /note="C-X-C chemokine receptor type 5"
FT /id="PRO_0000069360"
FT TOPO_DOM 1..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..219
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 122..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..45
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:7639692"
FT /id="VSP_001892"
FT VARIANT 34
FT /note="E -> K (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035757"
FT VARIANT 344
FT /note="G -> S (in dbSNP:rs665648)"
FT /id="VAR_011838"
SQ SEQUENCE 372 AA; 41955 MW; 6DF84C839492ACCF CRC64;
MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL
IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF
LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL
ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG
VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL
SESENATSLT TF
