CXCR5_RAT
ID CXCR5_RAT Reviewed; 374 AA.
AC P34997;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=C-X-C chemokine receptor type 5;
DE Short=CXC-R5;
DE Short=CXCR-5;
DE AltName: Full=Burkitt lymphoma receptor 1 homolog;
DE AltName: Full=Neurolymphatic receptor;
DE Short=NLR;
DE AltName: CD_antigen=CD185;
GN Name=Cxcr5; Synonyms=Blr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Spleen;
RX PubMed=8386678; DOI=10.1016/0014-5793(93)80102-z;
RA Kouba M., Vanetti M., Wang X., Schaefer M., Hoellt V.;
RT "Cloning of a novel putative G-protein-coupled receptor (NLR) which is
RT expressed in neuronal and lymphatic tissue.";
RL FEBS Lett. 321:173-178(1993).
CC -!- FUNCTION: Cytokine receptor that binds to B-lymphocyte chemoattractant
CC (BLC). Involved in B-cell migration into B-cell follicles of spleen and
CC Peyer patches but not into those of mesenteric or peripheral lymph
CC nodes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in neuronal and lymphatic tissue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X71463; CAA50582.1; -; Genomic_DNA.
DR PIR; S32785; S32785.
DR RefSeq; NP_445755.1; NM_053303.1.
DR AlphaFoldDB; P34997; -.
DR SMR; P34997; -.
DR STRING; 10116.ENSRNOP00000016580; -.
DR GlyGen; P34997; 2 sites.
DR PhosphoSitePlus; P34997; -.
DR PaxDb; P34997; -.
DR GeneID; 29363; -.
DR KEGG; rno:29363; -.
DR UCSC; RGD:62010; rat.
DR CTD; 643; -.
DR RGD; 62010; Cxcr5.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P34997; -.
DR OrthoDB; 794531at2759; -.
DR PhylomeDB; P34997; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P34997; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0030595; P:leukocyte chemotaxis; ISO:RGD.
DR GO; GO:0048535; P:lymph node development; ISO:RGD.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR001053; Chemokine_CXCR5.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00564; CXCCHMKINER5.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..374
FT /note="C-X-C chemokine receptor type 5"
FT /id="PRO_0000069362"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..90
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 124..204
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 374 AA; 42013 MW; D87A3AC816207319 CRC64;
MNSPISLDMG AITYNMDDLY KELAIYSNST EIPLQDSIFC STEEGPLLTS FKTIFMPVAY
SLIFLLGMMG NILVLVILER HRHTRSSTET FLFHLAVADL LLVFILPFAV AEGSVGWVLG
TFLCKTVIAL HKINFYCSSL LLACIAVDRY LAIVHAVHAY RRRRLLSIHI TCSTIWLAGF
LFALPELLFA KVVQPHNNES LPQCIFSQEN EAETRAWFAS RFLYHTGGFL LPMLVMAWCY
VGVVHRLLQA QRRPQRQKAV RVAILVTSIF LLCWSPYHIV IFLDTLERLK AVNSSCELSG
YLSVAITLCE FLGLAHCCLN PMLYTFAGVK FRSDLSRLLT KLGCAGPASL CQLFPGWRKS
SLSESENATS LTTF
