ID   CXCR6_CERAT             Reviewed;         343 AA.
AC   Q9N0Z0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=C-X-C chemokine receptor type 6;
DE            Short=CXC-R6;
DE            Short=CXCR-6;
DE   AltName: Full=G-protein coupled receptor STRL33;
DE   AltName: Full=G-protein coupled receptor bonzo;
DE   AltName: CD_antigen=CD186;
GN   Name=CXCR6; Synonyms=BONZO, STRL33;
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10799581; DOI=10.1128/jvi.74.11.5075-5082.2000;
RA   Pohlmann S., Lee B., Meister S., Krumbiegel M., Leslie G., Doms R.W.,
RA   Kirchhoff F.;
RT   "Simian immunodeficiency virus utilizes human and sooty mangabey but not
RT   rhesus macaque STRL33 for efficient entry.";
RL   J. Virol. 74:5075-5082(2000).
CC   -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC       by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF237559; AAF68392.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9N0Z0; -.
DR   SMR; Q9N0Z0; -.
DR   STRING; 9531.ENSCATP00000018056; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   CDD; cd15173; 7tmA_CXCR6; 1.
DR   InterPro; IPR002235; Chemokine_CXCR6.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF705; PTHR10489:SF705; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01105; CXCCHMKINER6.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..343
FT                   /note="C-X-C chemokine receptor type 6"
FT                   /id="PRO_0000069364"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..60
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..69
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..232
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..294
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        17
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        103..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   343 AA;  39589 MW;  A75B7A0751C13455 CRC64;
     MAEYDHYEDD EFFNSFNDSS QKEHQDFLQF SKVFLPCMYL VVFVCGLVGN SLVLVISIFY
     HKLQSLTDVF LVNLPLADLV FVCTLPFWAY AGIHEWIFGQ VMCKTLLGVY TINFYTSMLI
     LTCITVDRFI VVVKATKAYN QQAKRMTWGK VICLLIWVIS LLVSLPQIIY GNVFNLDKLI
     CRYHDEEIST VVLATQMTLG FFLPLLTMIV CYSVIIKTLL HAGGFQKHRS LKIIFLVMAV
     FLLTQTPFNL VKLIRSTHWE YYAMTSFHYT IIVTEAIAYL RACLNPVLYA FVSLKFRKNF
     WKLVKDIGCL PYLGVSHQWK SSEDNSKTFS ASHNVEATSM FQL