CXCR6_HUMAN
ID CXCR6_HUMAN Reviewed; 342 AA.
AC O00574; O00575; Q9HCA5;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=C-X-C chemokine receptor type 6;
DE Short=CXC-R6;
DE Short=CXCR-6;
DE AltName: Full=CDw186;
DE AltName: Full=G-protein coupled receptor STRL33;
DE AltName: Full=G-protein coupled receptor bonzo;
DE AltName: CD_antigen=CD186;
GN Name=CXCR6; Synonyms=BONZO, STRL33, TYMSTR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9230441; DOI=10.1038/40894;
RA Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.;
RT "Expression cloning of new receptors used by simian and human
RT immunodeficiency viruses.";
RL Nature 388:296-300(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-25.
RX PubMed=9166430; DOI=10.1084/jem.185.11.2015;
RA Liao F., Alkhatib G., Peden K.W.C., Sharma G., Berger E.A., Farber J.M.;
RT "STRL33, A novel chemokine receptor-like protein, functions as a fusion
RT cofactor for both macrophage-tropic and T cell line-tropic HIV-1.";
RL J. Exp. Med. 185:2015-2023(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RX PubMed=9285716; DOI=10.1016/s0960-9822(06)00292-2;
RA Loetscher M., Amara A., Oberlin E., Brass N., Legler D.F., Loetscher P.,
RA D'Apuzzo M., Meese E.U., Rousset D., Virelizier J.-L., Baggiolini M.,
RA Arenzana-Seisdedos F., Moser B.;
RT "TYMSTR, a putative chemokine receptor selectively expressed in activated T
RT cells, exhibits HIV-1 coreceptor function.";
RL Curr. Biol. 7:652-660(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-3.
RA An P., Winkler C., O'Brien S.J.;
RT "The influence of a STRL33 mutant on the course of HIV-1 infection.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in lymphoid tissues and activated T
CC cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry;
CC URL="https://en.wikipedia.org/wiki/CXC_chemokine_receptors";
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DR EMBL; AF007545; AAB64221.1; -; mRNA.
DR EMBL; U73529; AAB61456.1; -; mRNA.
DR EMBL; U73531; AAB61457.1; -; mRNA.
DR EMBL; Y13248; CAA73698.1; -; mRNA.
DR EMBL; AF029759; AAG21918.1; -; Genomic_DNA.
DR EMBL; AY322543; AAP84356.1; -; Genomic_DNA.
DR EMBL; BC033584; AAH33584.1; -; mRNA.
DR CCDS; CCDS2735.1; -.
DR RefSeq; NP_006555.1; NM_006564.1.
DR RefSeq; XP_005264866.1; XM_005264809.2.
DR RefSeq; XP_011531592.1; XM_011533290.2.
DR RefSeq; XP_011531593.1; XM_011533291.2.
DR AlphaFoldDB; O00574; -.
DR SMR; O00574; -.
DR STRING; 9606.ENSP00000395704; -.
DR BindingDB; O00574; -.
DR ChEMBL; CHEMBL5994; -.
DR GuidetoPHARMACOLOGY; 73; -.
DR GlyGen; O00574; 1 site.
DR iPTMnet; O00574; -.
DR PhosphoSitePlus; O00574; -.
DR BioMuta; CXCR6; -.
DR MassIVE; O00574; -.
DR PaxDb; O00574; -.
DR PeptideAtlas; O00574; -.
DR PRIDE; O00574; -.
DR Antibodypedia; 12723; 726 antibodies from 44 providers.
DR DNASU; 10663; -.
DR Ensembl; ENST00000304552.5; ENSP00000304414.4; ENSG00000172215.6.
DR Ensembl; ENST00000438735.1; ENSP00000396218.1; ENSG00000172215.6.
DR Ensembl; ENST00000457814.1; ENSP00000396886.1; ENSG00000172215.6.
DR Ensembl; ENST00000458629.1; ENSP00000395704.1; ENSG00000172215.6.
DR GeneID; 10663; -.
DR KEGG; hsa:10663; -.
DR MANE-Select; ENST00000304552.5; ENSP00000304414.4; NM_006564.2; NP_006555.1.
DR UCSC; uc003cpc.2; human.
DR CTD; 10663; -.
DR DisGeNET; 10663; -.
DR GeneCards; CXCR6; -.
DR HGNC; HGNC:16647; CXCR6.
DR HPA; ENSG00000172215; Tissue enhanced (lymphoid).
DR MIM; 605163; gene.
DR neXtProt; NX_O00574; -.
DR OpenTargets; ENSG00000172215; -.
DR PharmGKB; PA38409; -.
DR VEuPathDB; HostDB:ENSG00000172215; -.
DR eggNOG; ENOG502QSJQ; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; O00574; -.
DR OMA; VMCKTLL; -.
DR OrthoDB; 886529at2759; -.
DR PhylomeDB; O00574; -.
DR TreeFam; TF330966; -.
DR PathwayCommons; O00574; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; O00574; -.
DR BioGRID-ORCS; 10663; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; CXCR6; human.
DR GeneWiki; CXCR6; -.
DR GenomeRNAi; 10663; -.
DR Pharos; O00574; Tchem.
DR PRO; PR:O00574; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O00574; protein.
DR Bgee; ENSG00000172215; Expressed in spleen and 116 other tissues.
DR ExpressionAtlas; O00574; baseline and differential.
DR Genevisible; O00574; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0015026; F:coreceptor activity; TAS:ProtInc.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0019079; P:viral genome replication; TAS:ProtInc.
DR CDD; cd15173; 7tmA_CXCR6; 1.
DR InterPro; IPR002235; Chemokine_CXCR6.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF705; PTHR10489:SF705; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01105; CXCCHMKINER6.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="C-X-C chemokine receptor type 6"
FT /id="PRO_0000069365"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 3
FT /note="E -> K (in dbSNP:rs2234355)"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_024253"
FT VARIANT 25
FT /note="D -> A (in STRL33.3)"
FT /evidence="ECO:0000269|PubMed:9166430"
FT /id="VAR_003506"
SQ SEQUENCE 342 AA; 39280 MW; 9FBC025556D1082E CRC64;
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH
KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL
TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC
GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF
LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
