ID   CXCR6_MACNE             Reviewed;         342 AA.
AC   O19024;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=C-X-C chemokine receptor type 6;
DE            Short=CXC-R6;
DE            Short=CXCR-6;
DE   AltName: Full=G-protein coupled receptor bonzo;
DE   AltName: CD_antigen=CD186;
GN   Name=CXCR6; Synonyms=BONZO;
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9230441; DOI=10.1038/40894;
RA   Deng H.K., Unutmaz D., Kewalramani V.N., Littman D.R.;
RT   "Expression cloning of new receptors used by simian and human
RT   immunodeficiency viruses.";
RL   Nature 388:296-300(1997).
CC   -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC       by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF007858; AAB64224.1; -; Genomic_DNA.
DR   AlphaFoldDB; O19024; -.
DR   SMR; O19024; -.
DR   STRING; 9545.ENSMNEP00000026508; -.
DR   Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   CDD; cd15173; 7tmA_CXCR6; 1.
DR   InterPro; IPR002235; Chemokine_CXCR6.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF705; PTHR10489:SF705; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01105; CXCCHMKINER6.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..342
FT                   /note="C-X-C chemokine receptor type 6"
FT                   /id="PRO_0000069368"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..125
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..231
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..342
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        102..180
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   342 AA;  39298 MW;  55F9F68CB62D2DF5 CRC64;
     MAEHDYHEDY GLNSFNDSSQ EEHQDFLQFR KVFLPCMYLV VFVCGLVGNS LVLVISIFYH
     KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWIFGQV MCKTLLGVYT INFYTSMLIL
     TCITVDRFIV VVKATKAYNQ QAKRMTWGKV ICLLIWVISL LVSLPQIIYG NVFNLDKLIC
     GYHDKEISTV VLATQMTLGF FLPLLAMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF
     LLTQTPFNLV KLIRSTHWEY YAMTSFHYTI IVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
     KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL