CXCR6_PANTR
ID CXCR6_PANTR Reviewed; 342 AA.
AC Q9TV16;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=C-X-C chemokine receptor type 6;
DE Short=CXC-R6;
DE Short=CXCR-6;
DE AltName: Full=G-protein coupled receptor STRL33;
DE AltName: Full=G-protein coupled receptor bonzo;
DE AltName: CD_antigen=CD186;
GN Name=CXCR6; Synonyms=BONZO, STRL33;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10505680; DOI=10.1089/088922299310214;
RA Brussel A., Pretet J.-L., Girard M., Butor C.;
RT "Sequences and predicted structures of chimpanzee STRL33 (Bonzo) and gpr15
RT (BOB).";
RL AIDS Res. Hum. Retroviruses 15:1315-1319(1999).
CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF084229; AAD52041.1; -; mRNA.
DR RefSeq; NP_001009051.1; NM_001009051.1.
DR AlphaFoldDB; Q9TV16; -.
DR SMR; Q9TV16; -.
DR STRING; 9598.ENSPTRP00000054532; -.
DR PaxDb; Q9TV16; -.
DR Ensembl; ENSPTRT00000061984; ENSPTRP00000054532; ENSPTRG00000014843.
DR GeneID; 450138; -.
DR KEGG; ptr:450138; -.
DR CTD; 10663; -.
DR VGNC; VGNC:8832; CXCR6.
DR eggNOG; ENOG502QSJQ; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q9TV16; -.
DR OMA; VMCKTLL; -.
DR OrthoDB; 886529at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000014843; Expressed in skeletal muscle tissue and 13 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR CDD; cd15173; 7tmA_CXCR6; 1.
DR InterPro; IPR002235; Chemokine_CXCR6.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF705; PTHR10489:SF705; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01105; CXCCHMKINER6.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="C-X-C chemokine receptor type 6"
FT /id="PRO_0000069369"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 342 AA; 39273 MW; 5B58003797806B2A CRC64;
MAEHDYHEDY GFNSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH
KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL
TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC
GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF
LLTQMPFNLM KLIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
