ID   CXD2_LEUER              Reviewed;         302 AA.
AC   P69998; Q91323; Q91324; Q92107;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Gap junction delta-2 protein;
DE   AltName: Full=Connexin-35;
DE            Short=Cx35;
DE   AltName: Full=Gap junction alpha-9 protein;
OS   Leucoraja erinacea (Little skate) (Raja erinacea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Rajiformes; Rajidae; Leucoraja.
OX   NCBI_TaxID=7782;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Retina;
RX   PubMed=8688555; DOI=10.1091/mbc.7.2.233;
RA   O'Brien J., Al-Ubaidi M.R., Ripps H.;
RT   "Connexin 35: a gap-junctional protein expressed preferentially in the
RT   skate retina.";
RL   Mol. Biol. Cell 7:233-243(1996).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Retinal specific.
CC   -!- SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U43288; AAB09720.1; -; Genomic_DNA.
DR   EMBL; U43289; AAB09721.1; -; Genomic_DNA.
DR   AlphaFoldDB; P69998; -.
DR   SMR; P69998; -.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 2.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="Gap junction delta-2 protein"
FT                   /id="PRO_0000057838"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..232
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  35044 MW;  4571E4C405780BDC CRC64;
     MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILVVAI VGETVYDDEQ TMFVCNTLQP
     GCNQACYDKA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ SSKQRERQYS TVFITLDKDK
     KREDNKIKNT TVNGVLQNSE FFTKEMQSDF LEVKEMQNSA ARNSKMSKIR RQEGISRFYI
     IQVVFRNALE IGFLMGQYFL YGFKVPSMYE CNRYPCVKMV ECYVSRPTEK TVFLVFMFAV
     SGLCVILNLA ELNHLGWRKI KTAVRGAQER RKSIYEIRNK DSPHRIGVPN FGRTQSSDSA
     YV