CXD2_RAT
ID CXD2_RAT Reviewed; 321 AA.
AC O70610; Q9ER25;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Gap junction delta-2 protein;
DE AltName: Full=Connexin-36;
DE Short=Cx36;
DE AltName: Full=Gap junction alpha-9 protein;
GN Name=Gjd2; Synonyms=Gja9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=9645468; DOI=10.1016/s0014-5793(98)00479-7;
RA Soehl G., Degen J., Teubner B., Willecke K.;
RT "The murine gap junction gene connexin36 is highly expressed in mouse
RT retina and regulated during brain development.";
RL FEBS Lett. 428:27-31(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Retina;
RA Hidaka S.;
RT "Expression and localization of neuronal gap junction channel proteins in
RT rat retina and brain, revealed with antisera raised to connexin36.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- TISSUE SPECIFICITY: Highly expressed in neurons.
CC -!- SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
CC {ECO:0000305}.
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DR EMBL; Y16898; CAA76528.1; -; mRNA.
DR EMBL; AJ296282; CAC14913.1; -; mRNA.
DR RefSeq; NP_062154.1; NM_019281.2.
DR AlphaFoldDB; O70610; -.
DR SMR; O70610; -.
DR DIP; DIP-60789N; -.
DR IntAct; O70610; 1.
DR STRING; 10116.ENSRNOP00000011078; -.
DR PaxDb; O70610; -.
DR Ensembl; ENSRNOT00000011078; ENSRNOP00000011078; ENSRNOG00000008337.
DR GeneID; 50564; -.
DR KEGG; rno:50564; -.
DR UCSC; RGD:2694; rat.
DR CTD; 57369; -.
DR RGD; 2694; Gjd2.
DR eggNOG; ENOG502QV4X; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR HOGENOM; CLU_037388_4_0_1; -.
DR InParanoid; O70610; -.
DR OMA; KEMEPDC; -.
DR OrthoDB; 872373at2759; -.
DR PhylomeDB; O70610; -.
DR TreeFam; TF329606; -.
DR Reactome; R-RNO-112303; Electric Transmission Across Gap Junctions.
DR Reactome; R-RNO-190861; Gap junction assembly.
DR PRO; PR:O70610; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000008337; Expressed in cerebellum and 7 other tissues.
DR Genevisible; O70610; RN.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0005921; C:gap junction; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0001508; P:action potential; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; IEP:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; ISO:RGD.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002260; Connexin36.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01131; CONNEXIN36.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Gap junction delta-2 protein"
FT /id="PRO_0000057837"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 120..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 57
FT /note="T -> A (in Ref. 2; CAC14913)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 36052 MW; 63D4C108214AEF5E CRC64;
MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ TMFVCNTLQP
GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ SAKQRERRYS TVFLALDRDP
AESIGGPGGT GGGGSGGSKR EDKKLQNAIV NGVLQNTETT SKETEPDCLE VKELAPHPSG
LRTAARSKLR RQEGISRFYI IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV
ECYVSRPTEK TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK
DLPRVSVPNF GRTQSSDSAY V
