CXD3_MOUSE
ID CXD3_MOUSE Reviewed; 278 AA.
AC Q91YD1; Q80ZH0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Gap junction delta-3 protein;
DE AltName: Full=Connexin-30.2;
DE Short=Cx30.2;
DE AltName: Full=Gap junction alpha-11 protein;
DE AltName: Full=Gap junction chi-1 protein;
GN Name=Gjd3; Synonyms=Gja11, Gjc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=12108537; DOI=10.1515/bc.2002.076;
RA Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M.,
RA Deutsch U., Soehl G.;
RT "Structural and functional diversity of connexin genes in the mouse and
RT human genome.";
RL Biol. Chem. 383:725-737(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=12681499; DOI=10.1016/s0014-5793(03)00252-7;
RA Nielsen P.A., Kumar N.M.;
RT "Differences in expression patterns between mouse connexin-30.2 (Cx30.2)
RT and its putative human orthologue, connexin-31.9.";
RL FEBS Lett. 540:151-156(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ414561; CAC93843.1; -; Genomic_DNA.
DR EMBL; AY166870; AAN65188.1; -; Genomic_DNA.
DR EMBL; AL591067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25369.1; -.
DR RefSeq; NP_848711.2; NM_178596.2.
DR AlphaFoldDB; Q91YD1; -.
DR SMR; Q91YD1; -.
DR BioGRID; 237256; 1.
DR STRING; 10090.ENSMUSP00000055246; -.
DR iPTMnet; Q91YD1; -.
DR PhosphoSitePlus; Q91YD1; -.
DR PaxDb; Q91YD1; -.
DR PRIDE; Q91YD1; -.
DR Antibodypedia; 51141; 33 antibodies from 13 providers.
DR DNASU; 353155; -.
DR Ensembl; ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
DR GeneID; 353155; -.
DR KEGG; mmu:353155; -.
DR UCSC; uc007lib.1; mouse.
DR CTD; 125111; -.
DR MGI; MGI:2384150; Gjd3.
DR VEuPathDB; HostDB:ENSMUSG00000047197; -.
DR eggNOG; ENOG502R6H2; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR HOGENOM; CLU_037388_4_2_1; -.
DR InParanoid; Q91YD1; -.
DR OMA; RRARRCY; -.
DR OrthoDB; 1263142at2759; -.
DR PhylomeDB; Q91YD1; -.
DR TreeFam; TF329606; -.
DR Reactome; R-MMU-190861; Gap junction assembly.
DR BioGRID-ORCS; 353155; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Gjd3; mouse.
DR PRO; PR:Q91YD1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91YD1; protein.
DR Bgee; ENSMUSG00000047197; Expressed in spermatocyte and 26 other tissues.
DR ExpressionAtlas; Q91YD1; baseline and differential.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0005922; C:connexin complex; IGI:MGI.
DR GO; GO:0005921; C:gap junction; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005243; F:gap junction channel activity; ISO:MGI.
DR GO; GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IMP:BHF-UCL.
DR GO; GO:0005216; F:ion channel activity; IDA:MGI.
DR GO; GO:0086053; P:AV node cell to bundle of His cell communication by electrical coupling; IMP:BHF-UCL.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0016264; P:gap junction assembly; ISS:UniProtKB.
DR GO; GO:1903780; P:negative regulation of cardiac conduction; IMP:BHF-UCL.
DR GO; GO:1901845; P:negative regulation of cell communication by electrical coupling involved in cardiac conduction; IMP:BHF-UCL.
DR GO; GO:0010459; P:negative regulation of heart rate; IMP:BHF-UCL.
DR GO; GO:0009749; P:response to glucose; ISO:MGI.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..278
FT /note="Gap junction delta-3 protein"
FT /id="PRO_0000313009"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 223..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 13..16
FT /note="AVQL -> PLQV (in Ref. 2; AAN65188)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="A -> S (in Ref. 2; AAN65188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 30220 MW; A8A3DC827D070DE9 CRC64;
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE EFVCNTLQPG
CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA SKEAGGAQLA PPCARGRAEA
PCSPCALRAR RARRCYLLSV ALRLLAELAF LGGQALLYGF RVDPHYACAG PPCPHTVDCF
VSRPTEKTVF VVFYFAVGLL SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD
PFGPPAYAHR SPAGDSEGEG GSGHSKASLA TVRQDLAI
