ID   CXD4_MACFA              Reviewed;         370 AA.
AC   Q9N0B3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Gap junction delta-4 protein;
DE   AltName: Full=Connexin-40.1;
DE            Short=Cx40.1;
GN   Name=GJD4; ORFNames=QccE-15512;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB01599.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB046017; BAB01599.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001306359.1; NM_001319430.1.
DR   STRING; 9541.XP_005565052.1; -.
DR   PRIDE; Q9N0B3; -.
DR   GeneID; 102131448; -.
DR   CTD; 219770; -.
DR   eggNOG; ENOG502QWIV; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="Gap junction delta-4 protein"
FT                   /id="PRO_0000313010"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..370
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          227..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   370 AA;  40019 MW;  EDDA3D75424E4C16 CRC64;
     MEGVDLLGFL IITLNCNVTM XGKLWFVLTM LLRMLVIVLA GRPVYQDEQE RFVCNTLQPG
     CANVCYDVFS PVSHLRFWLI QGVCVLLPSA VFSVYVLHRG ATLAALGPRR CPEPRDTASG
     QRRCPGSCRE RGGLEVPDFS AGYIIHLLLR TLLEAAFGAL NYLLFGFLAP NKFPCTRPPC
     TGVVDCYVSR PTEKSLLMLF LWAVSALSFL LGLADLVCSL RRLMRRRPGP PTSPSIRKQS
     GAPGHPEGRP TDKEGGREQE GAPAPPVARA GGEGAGSPRV TSRVSGHTKI PDEDASEVTS
     SASEKLGRQP RGRPYREAAQ DPRGSGSEEQ PSAAPSHLAA HPSCSRLQPP DPPASSVGAP
     HLRARKSEWV