CXE18_ARATH
ID CXE18_ARATH Reviewed; 335 AA.
AC Q9LT10; Q8L8W1;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Probable carboxylesterase 18;
DE AltName: Full=AtCXE18;
DE EC=3.1.1.1;
GN Name=CXE18; OrderedLocusNames=At5g23530; ORFNames=MQM1.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14738307; DOI=10.1007/s00239-003-2492-8;
RA Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.;
RT "The carboxylesterase gene family from Arabidopsis thaliana.";
RL J. Mol. Evol. 57:487-500(2003).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- FUNCTION: Carboxylesterase acting on esters with varying acyl chain
CC length. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC -!- TISSUE SPECIFICITY: Expressed in roots, flowers and siliques.
CC {ECO:0000269|PubMed:14738307}.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB025633; BAA97248.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93179.1; -; Genomic_DNA.
DR EMBL; AK226851; BAE98944.1; -; mRNA.
DR EMBL; BT028935; ABI49482.1; -; mRNA.
DR EMBL; AY088776; AAM67089.1; -; mRNA.
DR RefSeq; NP_197744.1; NM_122260.4.
DR AlphaFoldDB; Q9LT10; -.
DR SMR; Q9LT10; -.
DR STRING; 3702.AT5G23530.1; -.
DR ESTHER; arath-CXE18; Plant_carboxylesterase.
DR MEROPS; S09.A10; -.
DR iPTMnet; Q9LT10; -.
DR PaxDb; Q9LT10; -.
DR PRIDE; Q9LT10; -.
DR ProteomicsDB; 220376; -.
DR EnsemblPlants; AT5G23530.1; AT5G23530.1; AT5G23530.
DR GeneID; 832418; -.
DR Gramene; AT5G23530.1; AT5G23530.1; AT5G23530.
DR KEGG; ath:AT5G23530; -.
DR Araport; AT5G23530; -.
DR TAIR; locus:2171681; AT5G23530.
DR eggNOG; KOG1515; Eukaryota.
DR HOGENOM; CLU_012494_22_1_1; -.
DR InParanoid; Q9LT10; -.
DR OMA; RYISPGM; -.
DR OrthoDB; 1263520at2759; -.
DR PhylomeDB; Q9LT10; -.
DR BioCyc; ARA:AT5G23530-MON; -.
DR PRO; PR:Q9LT10; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LT10; baseline and differential.
DR Genevisible; Q9LT10; AT.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IDA:TAIR.
DR GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR GO; GO:0009860; P:pollen tube growth; IEP:TAIR.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR Pfam; PF07859; Abhydrolase_3; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Acetylation; Hydrolase; Reference proteome; Serine esterase.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..335
FT /note="Probable carboxylesterase 18"
FT /id="PRO_0000402562"
FT MOTIF 94..96
FT /note="Involved in the stabilization of the negatively
FT charged intermediate by the formation of the oxyanion hole"
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 173
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 274
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 304
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CONFLICT 300
FT /note="P -> S (in Ref. 5; AAM67089)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37715 MW; 6A265F9E310C676C CRC64;
MATDSQPNQK LTLPLKTRIA LTVISTMTDN AQRPDGTINR RFLRLFDFRA PPNPKPVNIV
STSDFVVDQS RDLWFRLYTP HVSGDKIPVV VFFHGGGFAF LSPNAYPYDN VCRRFARKLP
AYVISVNYRL APEHRYPAQY DDGFDALKYI EENHGSILPA NADLSRCFFA GDSAGGNIAH
NVAIRICREP RSSFTAVKLI GLISIQPFFG GEERTEAEKQ LVGAPLVSPD RTDWCWKAMG
LNRDHEAVNV GGPNAVDISG LDYPETMVVV AGFDPLKDWQ RSYYEWLKLC GKKATLIEYP
NMFHAFYIFP ELPEAGQLIM RIKDFVDERV ASLSA