ID   CXE3_CONIM              Reviewed;          73 AA.
AC   P0DUB0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Conotoxin Im14.3 {ECO:0000305};
DE   AltName: Full=Conopeptide im031 {ECO:0000303|PubMed:30893765};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- PTM: Contain 2 disulfide bonds. {ECO:0000305}.
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DR   AlphaFoldDB; P0DUB0; -.
DR   SMR; P0DUB0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003582; ShKT_dom.
DR   Pfam; PF01549; ShK; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..35
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000451010"
FT   CHAIN           36..71
FT                   /note="Conotoxin Im14.3"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179760"
FT   REGION          22..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   73 AA;  8034 MW;  5D059F54F76B79AF CRC64;
     MGVFRCCLAA ALVVVCLSRM GGTEPLESNH EDERRADDTS GDDCVDTNED CVNWASTGQC
     EANPSYMREN CRK