CXE5_ARATH
ID CXE5_ARATH Reviewed; 319 AA.
AC Q9FX94;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable carboxylesterase 5;
DE AltName: Full=AtCXE5;
DE EC=3.1.1.1;
GN Name=CXE5; OrderedLocusNames=At1g49660; ORFNames=F14J22.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14738307; DOI=10.1007/s00239-003-2492-8;
RA Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.;
RT "The carboxylesterase gene family from Arabidopsis thaliana.";
RL J. Mol. Evol. 57:487-500(2003).
CC -!- FUNCTION: Carboxylesterase acting on esters with varying acyl chain
CC length. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+);
CC Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers and
CC siliques. {ECO:0000269|PubMed:14738307}.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000305}.
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DR EMBL; AC011807; AAG13052.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32456.1; -; Genomic_DNA.
DR EMBL; BT022077; AAY27064.1; -; mRNA.
DR PIR; C96533; C96533.
DR RefSeq; NP_175389.1; NM_103854.3.
DR AlphaFoldDB; Q9FX94; -.
DR SMR; Q9FX94; -.
DR STRING; 3702.AT1G49660.1; -.
DR ESTHER; arath-F14J22.11; Plant_carboxylesterase.
DR iPTMnet; Q9FX94; -.
DR PaxDb; Q9FX94; -.
DR PRIDE; Q9FX94; -.
DR ProteomicsDB; 220516; -.
DR EnsemblPlants; AT1G49660.1; AT1G49660.1; AT1G49660.
DR GeneID; 841390; -.
DR Gramene; AT1G49660.1; AT1G49660.1; AT1G49660.
DR KEGG; ath:AT1G49660; -.
DR Araport; AT1G49660; -.
DR TAIR; locus:2012227; AT1G49660.
DR eggNOG; KOG1515; Eukaryota.
DR HOGENOM; CLU_012494_22_0_1; -.
DR InParanoid; Q9FX94; -.
DR OMA; HMAMKAG; -.
DR OrthoDB; 1263520at2759; -.
DR PhylomeDB; Q9FX94; -.
DR BioCyc; ARA:AT1G49660-MON; -.
DR PRO; PR:Q9FX94; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FX94; baseline and differential.
DR Genevisible; Q9FX94; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IDA:TAIR.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR GO; GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR Pfam; PF07859; Abhydrolase_3; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Hydrolase; Reference proteome; Serine esterase.
FT CHAIN 1..319
FT /note="Probable carboxylesterase 5"
FT /id="PRO_0000402551"
FT MOTIF 79..81
FT /note="Involved in the stabilization of the negatively
FT charged intermediate by the formation of the oxyanion hole"
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 163
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 262
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT ACT_SITE 294
FT /evidence="ECO:0000250|UniProtKB:Q5NUF3"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9SMN0"
SQ SEQUENCE 319 AA; 35197 MW; D4604D56F70A4AF6 CRC64;
MESEIASEFL PFCRIYKDGR VERLIGTDTI PASLDPTYDV VSKDVIYSPE NNLSVRLFLP
HKSTKLTAGN KLPLLIYIHG GAWIIESPFS PLYHNYLTEV VKSANCLAVS VQYRRAPEDP
VPAAYEDVWS AIQWIFAHSN GSGPVDWINK HADFGKVFLG GDSAGGNISH HMAMKAGKEK
KLDLKIKGIA VVHPAFWGTD PVDEYDVQDK ETRSGIAEIW EKIASPNSVN GTDDPLFNVN
GSGSDFSGLG CDKVLVAVAG KDVFVRQGLA YAAKLEKCEW EGTVEVVEEE GEDHVFHLQN
PKSDKALKFL KKFVEFIIG