CXG1_CANLF
ID CXG1_CANLF Reviewed; 396 AA.
AC P28228; Q5J7U4;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Gap junction gamma-1 protein;
DE AltName: Full=Connexin-45;
DE Short=Cx45;
DE AltName: Full=Gap junction alpha-7 protein;
GN Name=GJC1; Synonyms=GJA7;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1310450; DOI=10.1161/01.res.70.2.438;
RA Kanter H.L., Saffitz J.E., Beyer E.C.;
RT "Cardiac myocytes express multiple gap junction proteins.";
RL Circ. Res. 70:438-444(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Werner P., Raducha M.G., Prociuk U., Ostrander E.A., Spielman R.S.,
RA Kirkness E.F., Henthorn P.S., Patterson D.F.;
RT "Genome-wide scan for conotruncal heart defect loci in a canine model.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC with CNST (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
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DR EMBL; M81348; AAA30839.1; -; Genomic_DNA.
DR EMBL; AY438630; AAR99071.1; -; Genomic_DNA.
DR PIR; B49024; B49024.
DR RefSeq; NP_001018648.1; NM_001020812.2.
DR RefSeq; XP_005624400.1; XM_005624343.2.
DR RefSeq; XP_005624401.1; XM_005624344.2.
DR AlphaFoldDB; P28228; -.
DR SMR; P28228; -.
DR STRING; 9615.ENSCAFP00000020776; -.
DR PaxDb; P28228; -.
DR PRIDE; P28228; -.
DR GeneID; 490936; -.
DR KEGG; cfa:490936; -.
DR CTD; 10052; -.
DR eggNOG; ENOG502QV2G; Eukaryota.
DR InParanoid; P28228; -.
DR OrthoDB; 692491at2759; -.
DR TreeFam; TF329606; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005922; C:connexin complex; IDA:BHF-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002265; Connexin45.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01136; CONNEXINA6.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..396
FT /note="Gap junction gamma-1 protein"
FT /id="PRO_0000057825"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..228
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 145..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 30
FT /note="A -> V (in Ref. 2; AAR99071)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="A -> V (in Ref. 2; AAR99071)"
FT /evidence="ECO:0000305"
FT CONFLICT 345
FT /note="V -> A (in Ref. 2; AAR99071)"
FT /evidence="ECO:0000305"
FT CONFLICT 392
FT /note="N -> T (in Ref. 2; AAR99071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 396 AA; 45533 MW; E72AB416178ED3CE CRC64;
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIA FRIALTAVGG ESIYYDEQSK FVCNTEQPGC
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR
WKQHRALEET EEDHEEDPMM YPEMELESEK ENKEQNQPKP KHDGRRRIRE DGLMKIYVLQ
LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG
LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
YTELSNAKIA YKQNKANIAQ EQQYGSHEEN LPADLETLQR EIKMVQERLD LAIQAYSHQN
NPHGPREKKA KVGSKAGSNK SSASSKSGDG KNSVWI
