CXG1_CHICK
ID CXG1_CHICK Reviewed; 394 AA.
AC P18861;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Gap junction gamma-1 protein;
DE AltName: Full=Connexin-45;
DE Short=Cx45;
DE AltName: Full=Gap junction alpha-7 protein;
GN Name=GJC1; Synonyms=GJA7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2167316; DOI=10.1016/s0021-9258(18)77321-3;
RA Beyer E.C.;
RT "Molecular cloning and developmental expression of two chick embryo gap
RT junction proteins.";
RL J. Biol. Chem. 265:14439-14443(1990).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- TISSUE SPECIFICITY: Mostly in heart and stomach.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
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DR EMBL; M35044; AAA48717.1; -; mRNA.
DR PIR; A37819; A37819.
DR RefSeq; NP_990834.1; NM_205503.1.
DR RefSeq; XP_015154699.1; XM_015299213.1.
DR RefSeq; XP_015154700.1; XM_015299214.1.
DR RefSeq; XP_015154701.1; XM_015299215.1.
DR RefSeq; XP_015154702.1; XM_015299216.1.
DR RefSeq; XP_015154704.1; XM_015299218.1.
DR RefSeq; XP_015154705.1; XM_015299219.1.
DR RefSeq; XP_015154706.1; XM_015299220.1.
DR RefSeq; XP_015154707.1; XM_015299221.1.
DR RefSeq; XP_015154708.1; XM_015299222.1.
DR AlphaFoldDB; P18861; -.
DR SMR; P18861; -.
DR STRING; 9031.ENSGALP00000001471; -.
DR PaxDb; P18861; -.
DR Ensembl; ENSGALT00000001473; ENSGALP00000001471; ENSGALG00000000997.
DR GeneID; 396501; -.
DR KEGG; gga:396501; -.
DR CTD; 349149; -.
DR VEuPathDB; HostDB:geneid_396501; -.
DR eggNOG; ENOG502QV2G; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR HOGENOM; CLU_037388_0_0_1; -.
DR InParanoid; P18861; -.
DR OMA; VRWKQHR; -.
DR OrthoDB; 692491at2759; -.
DR PhylomeDB; P18861; -.
DR TreeFam; TF329606; -.
DR Reactome; R-GGA-112303; Electric Transmission Across Gap Junctions.
DR Reactome; R-GGA-190861; Gap junction assembly.
DR PRO; PR:P18861; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000000997; Expressed in heart and 13 other tissues.
DR GO; GO:0005922; C:connexin complex; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IEA:Ensembl.
DR GO; GO:0005216; F:ion channel activity; IEA:Ensembl.
DR GO; GO:0048738; P:cardiac muscle tissue development; IEA:Ensembl.
DR GO; GO:0048468; P:cell development; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0016264; P:gap junction assembly; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002265; Connexin45.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01136; CONNEXINA6.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..394
FT /note="Gap junction gamma-1 protein"
FT /id="PRO_0000057828"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 354..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 45372 MW; A270AEDCD5FFCC93 CRC64;
MSWSFLTRLL EEIHNHSTFV GKIWLSVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA RMVEHSDVDR RFRSKSFSTR
WKQHRGLEEA EDDHEEDPMM YPEIELESER ENKEQQPPAK AKHDGRRRIR EDGLMRIYVL
QLLVRATFEV GFLIGQYLLY GFEVSPVFVC SRKPCPHKID CFISRPTEKT IFLLIMYGVS
CMCLLLNVWE MLHLGFGTIR DTLNNKRKEL EDSGTYNYPF TWNTPSAPPG YNIAVKPDQM
QYTELSNAKM AYKQNKANIA QEQQYGSNEE NIPADLENLQ REIKVAQERL DMAIQAYNNQ
NNPGSSSREK KSKAGSNKSS ASSKSGDGKN SVWI
