CXG1_PIG
ID CXG1_PIG Reviewed; 396 AA.
AC A4GVD1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Gap junction gamma-1 protein;
DE AltName: Full=Connexin-45;
DE Short=Cx45;
DE AltName: Full=Gap junction alpha-7 protein;
GN Name=GJC1; Synonyms=GJA7;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Urinary bladder;
RA Lehmann T., Dittrich R., John H., Maake C.;
RT "Expression of connexin 45 in the pig urinary bladder.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC with CNST (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF437944; ABO28479.1; -; mRNA.
DR RefSeq; NP_001090988.1; NM_001097519.1.
DR RefSeq; XP_005668761.1; XM_005668704.2.
DR RefSeq; XP_005668762.1; XM_005668705.2.
DR RefSeq; XP_005668763.1; XM_005668706.2.
DR RefSeq; XP_005668765.1; XM_005668708.2.
DR RefSeq; XP_013836322.1; XM_013980868.1.
DR AlphaFoldDB; A4GVD1; -.
DR SMR; A4GVD1; -.
DR STRING; 9823.ENSSSCP00000021968; -.
DR PaxDb; A4GVD1; -.
DR PRIDE; A4GVD1; -.
DR Ensembl; ENSSSCT00000030363; ENSSSCP00000021968; ENSSSCG00000021306.
DR Ensembl; ENSSSCT00000049822; ENSSSCP00000043247; ENSSSCG00000021306.
DR Ensembl; ENSSSCT00000051568; ENSSSCP00000040946; ENSSSCG00000021306.
DR Ensembl; ENSSSCT00000090660; ENSSSCP00000070627; ENSSSCG00000021306.
DR Ensembl; ENSSSCT00005066328; ENSSSCP00005041091; ENSSSCG00005041432.
DR Ensembl; ENSSSCT00005066340; ENSSSCP00005041097; ENSSSCG00005041432.
DR Ensembl; ENSSSCT00005066343; ENSSSCP00005041100; ENSSSCG00005041432.
DR Ensembl; ENSSSCT00015083049; ENSSSCP00015033594; ENSSSCG00015062216.
DR Ensembl; ENSSSCT00015083061; ENSSSCP00015033600; ENSSSCG00015062216.
DR Ensembl; ENSSSCT00015083083; ENSSSCP00015033612; ENSSSCG00015062216.
DR Ensembl; ENSSSCT00015083144; ENSSSCP00015033642; ENSSSCG00015062216.
DR Ensembl; ENSSSCT00025077396; ENSSSCP00025033544; ENSSSCG00025056612.
DR Ensembl; ENSSSCT00025077454; ENSSSCP00025033568; ENSSSCG00025056612.
DR Ensembl; ENSSSCT00025077505; ENSSSCP00025033590; ENSSSCG00025056612.
DR Ensembl; ENSSSCT00025077561; ENSSSCP00025033618; ENSSSCG00025056612.
DR Ensembl; ENSSSCT00025077622; ENSSSCP00025033644; ENSSSCG00025056612.
DR Ensembl; ENSSSCT00030083182; ENSSSCP00030038221; ENSSSCG00030059596.
DR Ensembl; ENSSSCT00030083199; ENSSSCP00030038229; ENSSSCG00030059596.
DR Ensembl; ENSSSCT00030083218; ENSSSCP00030038241; ENSSSCG00030059596.
DR Ensembl; ENSSSCT00030083232; ENSSSCP00030038246; ENSSSCG00030059596.
DR Ensembl; ENSSSCT00035098696; ENSSSCP00035041720; ENSSSCG00035072893.
DR Ensembl; ENSSSCT00035098701; ENSSSCP00035041725; ENSSSCG00035072893.
DR Ensembl; ENSSSCT00035098707; ENSSSCP00035041729; ENSSSCG00035072893.
DR Ensembl; ENSSSCT00035098710; ENSSSCP00035041731; ENSSSCG00035072893.
DR Ensembl; ENSSSCT00040052164; ENSSSCP00040021649; ENSSSCG00040039026.
DR Ensembl; ENSSSCT00040052187; ENSSSCP00040021660; ENSSSCG00040039026.
DR Ensembl; ENSSSCT00040052217; ENSSSCP00040021671; ENSSSCG00040039026.
DR Ensembl; ENSSSCT00040052238; ENSSSCP00040021679; ENSSSCG00040039026.
DR Ensembl; ENSSSCT00045024535; ENSSSCP00045016949; ENSSSCG00045014408.
DR Ensembl; ENSSSCT00045024549; ENSSSCP00045016958; ENSSSCG00045014408.
DR Ensembl; ENSSSCT00045024557; ENSSSCP00045016965; ENSSSCG00045014408.
DR Ensembl; ENSSSCT00045024565; ENSSSCP00045016970; ENSSSCG00045014408.
DR Ensembl; ENSSSCT00060103158; ENSSSCP00060044998; ENSSSCG00060075392.
DR Ensembl; ENSSSCT00060103166; ENSSSCP00060045004; ENSSSCG00060075392.
DR Ensembl; ENSSSCT00060103170; ENSSSCP00060045005; ENSSSCG00060075392.
DR Ensembl; ENSSSCT00060103174; ENSSSCP00060045010; ENSSSCG00060075392.
DR Ensembl; ENSSSCT00065044570; ENSSSCP00065019037; ENSSSCG00065032858.
DR Ensembl; ENSSSCT00065044574; ENSSSCP00065019039; ENSSSCG00065032858.
DR Ensembl; ENSSSCT00065044577; ENSSSCP00065019041; ENSSSCG00065032858.
DR Ensembl; ENSSSCT00065044580; ENSSSCP00065019043; ENSSSCG00065032858.
DR Ensembl; ENSSSCT00070018503; ENSSSCP00070015376; ENSSSCG00070009539.
DR Ensembl; ENSSSCT00070018510; ENSSSCP00070015382; ENSSSCG00070009539.
DR Ensembl; ENSSSCT00070018515; ENSSSCP00070015385; ENSSSCG00070009539.
DR GeneID; 100048959; -.
DR KEGG; ssc:100048959; -.
DR CTD; 10052; -.
DR VGNC; VGNC:88468; GJC1.
DR eggNOG; ENOG502QV2G; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR HOGENOM; CLU_037388_0_0_1; -.
DR InParanoid; A4GVD1; -.
DR OMA; VRWKQHR; -.
DR OrthoDB; 692491at2759; -.
DR TreeFam; TF329606; -.
DR Reactome; R-SSC-112303; Electric Transmission Across Gap Junctions.
DR Reactome; R-SSC-190861; Gap junction assembly.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Chromosome 12.
DR Bgee; ENSSSCG00000021306; Expressed in hindlimb bud and 41 other tissues.
DR Genevisible; A4GVD1; SS.
DR GO; GO:0005922; C:connexin complex; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IEA:Ensembl.
DR GO; GO:0005216; F:ion channel activity; IEA:Ensembl.
DR GO; GO:0048738; P:cardiac muscle tissue development; IEA:Ensembl.
DR GO; GO:0048468; P:cell development; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0016264; P:gap junction assembly; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002265; Connexin45.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01136; CONNEXINA6.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..396
FT /note="Gap junction gamma-1 protein"
FT /id="PRO_0000313006"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..228
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 145..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 45598 MW; DF10A8FD9C9A2F49 CRC64;
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR
WKQHRALEET EEDHEEDPMM YPEMELESEK ENKEQNQSKP KHDGRRRIRE DGLMKIYVLQ
LLARTMFEVG FLIGQYFLYG FQVHPFYVCS RVPCPHKIDC FISRPTEKTI FLLIMYGVTG
LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
YTELSNAKIA YKQNKANIAQ EQQYGSHEET LPADLETLQR EIRMAQERLD LAIQAYNHQN
NPHGPREKKA KVGSKAGSNK SSASSKSGDG KTSVWI
