CXG1_RAT
ID CXG1_RAT Reviewed; 396 AA.
AC A4GG66;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Gap junction gamma-1 protein;
DE AltName: Full=Connexin-45;
DE Short=Cx45;
DE AltName: Full=Gap junction alpha-7 protein;
GN Name=Gjc1; Synonyms=Gja7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Liver;
RX PubMed=17328669; DOI=10.1089/dna.2006.0540;
RA Teunissen B.E., Jansen A.T., Mutsaers N.A., Vuerhard M.J., Vos M.A.,
RA Bierhuizen M.F.;
RT "Primary structure, organization, and expression of the rat connexin45
RT gene.";
RL DNA Cell Biol. 26:108-115(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC with CNST (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17328669}.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ871218; ABI54096.1; -; Genomic_DNA.
DR EMBL; DQ871218; ABI54097.1; -; Genomic_DNA.
DR EMBL; DQ871218; ABI54098.1; -; Genomic_DNA.
DR EMBL; DQ871218; ABI54099.1; -; Genomic_DNA.
DR EMBL; CH473948; EDM06232.1; -; Genomic_DNA.
DR EMBL; BC166405; AAI66405.1; -; mRNA.
DR RefSeq; NP_001078850.1; NM_001085381.1.
DR RefSeq; XP_017452538.1; XM_017597049.1.
DR RefSeq; XP_017452539.1; XM_017597050.1.
DR AlphaFoldDB; A4GG66; -.
DR BMRB; A4GG66; -.
DR SMR; A4GG66; -.
DR STRING; 10116.ENSRNOP00000066371; -.
DR PaxDb; A4GG66; -.
DR Ensembl; ENSRNOT00000093570; ENSRNOP00000076255; ENSRNOG00000048838.
DR Ensembl; ENSRNOT00000096574; ENSRNOP00000081758; ENSRNOG00000048838.
DR Ensembl; ENSRNOT00000108179; ENSRNOP00000087322; ENSRNOG00000048838.
DR Ensembl; ENSRNOT00000116881; ENSRNOP00000096467; ENSRNOG00000048838.
DR Ensembl; ENSRNOT00000117898; ENSRNOP00000094267; ENSRNOG00000048838.
DR GeneID; 266706; -.
DR KEGG; rno:266706; -.
DR CTD; 10052; -.
DR RGD; 628889; Gjc1.
DR eggNOG; ENOG502QV2G; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR HOGENOM; CLU_037388_0_0_1; -.
DR InParanoid; A4GG66; -.
DR OMA; VRWKQHR; -.
DR OrthoDB; 692491at2759; -.
DR PhylomeDB; A4GG66; -.
DR Reactome; R-RNO-112303; Electric Transmission Across Gap Junctions.
DR Reactome; R-RNO-190861; Gap junction assembly.
DR PRO; PR:A4GG66; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Proteomes; UP000234681; Chromosome 10.
DR Bgee; ENSRNOG00000048838; Expressed in quadriceps femoris and 19 other tissues.
DR Genevisible; A4GG66; RN.
DR GO; GO:0005922; C:connexin complex; ISO:RGD.
DR GO; GO:0005921; C:gap junction; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005243; F:gap junction channel activity; IDA:RGD.
DR GO; GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; ISO:RGD.
DR GO; GO:0005216; F:ion channel activity; ISO:RGD.
DR GO; GO:0086053; P:AV node cell to bundle of His cell communication by electrical coupling; ISO:RGD.
DR GO; GO:0048738; P:cardiac muscle tissue development; ISO:RGD.
DR GO; GO:0048468; P:cell development; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; IDA:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; ISO:RGD.
DR GO; GO:0016264; P:gap junction assembly; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0001570; P:vasculogenesis; ISO:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002265; Connexin45.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01136; CONNEXINA6.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Coiled coil; Gap junction; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..396
FT /note="Gap junction gamma-1 protein"
FT /id="PRO_0000369543"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 145..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..358
FT /evidence="ECO:0000255"
FT COMPBIAS 375..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 45666 MW; 9CD5721BB071B65C CRC64;
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR
WKQHRALEET EEDHEEDPMM YPEMELESEK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ
LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG
LCLLLNIWEM LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD LAIQAYHHQN
NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI
