ID   CXG1_XENLA              Reviewed;         377 AA.
AC   Q7ZXS7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Gap junction gamma-1 protein;
DE   AltName: Full=Gap junction alpha-7 protein;
GN   Name=gjc1; Synonyms=gja7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC044270; AAH44270.1; -; mRNA.
DR   RefSeq; NP_001079553.1; NM_001086084.1.
DR   AlphaFoldDB; Q7ZXS7; -.
DR   SMR; Q7ZXS7; -.
DR   DNASU; 379240; -.
DR   GeneID; 379240; -.
DR   KEGG; xla:379240; -.
DR   CTD; 379240; -.
DR   Xenbase; XB-GENE-5905192; gja7.S.
DR   OMA; GETIYHD; -.
DR   OrthoDB; 766272at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 379240; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..377
FT                   /note="Gap junction gamma-1 protein"
FT                   /id="PRO_0000369544"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..174
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          129..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  43164 MW;  9906F4FEE6323D64 CRC64;
     MSWSFLTRLL EEINNHSTFV GKIWLTVLII FRIVLTAVGG ESIYYDEQSK FTCNTHQPGC
     ENVCYDAFAP LSHVRFWVFQ IILITTPSIM YLGFAMHRIA RQPDEQIRRL EKTKSKKRAP
     IIHRGAMRDY EEAEDNQEED PMICEEEEPE KDSEKGDKKK HDGRRRIKQD GLMKVYVLQL
     LFRSVFEVGF LMGQYVLYGF EVIPFFVCSR NPCPHTVDCF VSRPTEKTIF LLIMYAVSAL
     CLFLNLCELF HLGIGGIRDA LRQKRKEIQE SRKKKPSAPP NYHSVLKKGK LPNGKPVFPG
     NGVSEGFEMP VHELDRLRQH LKLAQEHLDL AFHLNPSADI AHASRSSSPE ANSIAAEQNR
     LNLAQEKGVG SREKSGL