ID   CXG1_XENTR              Reviewed;         377 AA.
AC   Q6NZH5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Gap junction gamma-1 protein;
DE   AltName: Full=Gap junction alpha-7 protein;
GN   Name=gjc1; Synonyms=gja7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC066131; AAH66131.1; -; mRNA.
DR   RefSeq; NP_991400.1; NM_205831.1.
DR   AlphaFoldDB; Q6NZH5; -.
DR   SMR; Q6NZH5; -.
DR   STRING; 8364.ENSXETP00000031475; -.
DR   PaxDb; Q6NZH5; -.
DR   DNASU; 403098; -.
DR   Ensembl; ENSXETT00000031475; ENSXETP00000031475; ENSXETG00000014395.
DR   GeneID; 403098; -.
DR   KEGG; xtr:403098; -.
DR   CTD; 403098; -.
DR   Xenbase; XB-GENE-5905096; gja7.
DR   eggNOG; ENOG502QVY2; Eukaryota.
DR   InParanoid; Q6NZH5; -.
DR   OrthoDB; 766272at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014395; Expressed in 4-cell stage embryo and 9 other tissues.
DR   ExpressionAtlas; Q6NZH5; differential.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..377
FT                   /note="Gap junction gamma-1 protein"
FT                   /id="PRO_0000369545"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..174
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..228
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          129..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  43190 MW;  6328E57348E46C0B CRC64;
     MSWSFLTRLL EEINNHSTFV GKVWLTVLII FRIVLTAVGG ESIYYDEQSK FTCNTQQPGC
     ENVCYDAFAP LSHVRFWVFQ IILITTPSIM YLGFAMHRIA RQPEMQIRRS EKTKSKKRAP
     IIHRGAMRDY EEAEDNQEED PMICEEEEPE KDSEKGDKKK HDGRRRIKQD GLMKVYVLQL
     LFRSVFEVGF LMGQYILYGF EVIPFFVCSR KPCPHTVDCF VSRPTEKTIF LLIMYAVSAL
     CLFLNLCELF HLGIGGIRDA LRQKKKELQE SRKKTPSAPP NYHSVLKKGR LPNGKPVFPG
     NGVSEGFELP THELDRLRQH LKLAQEHLDL AFHLNPTGDN THASRSSSPE SNSIAAEQNR
     LNLAQEKGVG NREKSGL