CXG2_BOVIN
ID CXG2_BOVIN Reviewed; 429 AA.
AC Q29RK8;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Gap junction gamma-2 protein;
DE AltName: Full=Gap junction alpha-12 protein;
GN Name=GJC2; Synonyms=GJA12;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. May play a role
CC in myelination in central and peripheral nervous systems (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts
CC with TJP1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
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DR EMBL; BC114129; AAI14130.1; -; mRNA.
DR RefSeq; NP_001039905.1; NM_001046440.1.
DR RefSeq; XP_005208463.1; XM_005208406.3.
DR RefSeq; XP_005208464.1; XM_005208407.3.
DR AlphaFoldDB; Q29RK8; -.
DR SMR; Q29RK8; -.
DR STRING; 9913.ENSBTAP00000019857; -.
DR PaxDb; Q29RK8; -.
DR Ensembl; ENSBTAT00000019857; ENSBTAP00000019857; ENSBTAG00000014916.
DR GeneID; 538745; -.
DR KEGG; bta:538745; -.
DR CTD; 57165; -.
DR VEuPathDB; HostDB:ENSBTAG00000014916; -.
DR VGNC; VGNC:29383; GJC2.
DR eggNOG; ENOG502QV2G; Eukaryota.
DR GeneTree; ENSGT01050000244833; -.
DR InParanoid; Q29RK8; -.
DR OMA; PPYNYAY; -.
DR OrthoDB; 959629at2759; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000014916; Expressed in pons and 68 other tissues.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:1903763; F:gap junction channel activity involved in cell communication by electrical coupling; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..429
FT /note="Gap junction gamma-2 protein"
FT /id="PRO_0000244876"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 106..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..139
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BQU6"
SQ SEQUENCE 429 AA; 46067 MW; 068C71AFEBBE9E6B CRC64;
MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QTKFTCNTRQ
PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASQDER RRASRRRPSR
RAPRPPLPLP PPPHPGWPEP ADLGEEEPML GLGEEDEDPG VAEGLGEDEE AEDTGAAKGA
GGDTKVAGVP GPAGQHDGRR RIQREGLMRV YVAQLVARAA FEVAFLVGQY LLYGFEVRPF
FACSRQPCPH VVDCFVSRPT EKTVFLLVMY VVSCLCLLLN LCEMAHLGLG NAQDAVRGRR
PLPASPGPMP RPPPCALPAA PSGLACPPDY SLVVRTAEHA RAQDQELASL ALQALQDRRA
LGDLDSPPGP GLPANARGPP KPGAPASGSG SATSGGTVGG QGRQGIKPRM GSEKGSGSSS
REGKTTVWI
