ID   CXG3_BOVIN              Reviewed;         275 AA.
AC   A3KN25;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Gap junction gamma-3 protein;
DE   AltName: Full=Gap junction epsilon-1 protein;
GN   Name=GJC3; Synonyms=GJE1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC133515; AAI33516.1; -; mRNA.
DR   RefSeq; NP_001076962.1; NM_001083493.1.
DR   AlphaFoldDB; A3KN25; -.
DR   SMR; A3KN25; -.
DR   STRING; 9913.ENSBTAP00000051873; -.
DR   PaxDb; A3KN25; -.
DR   GeneID; 539991; -.
DR   KEGG; bta:539991; -.
DR   CTD; 349149; -.
DR   eggNOG; ENOG502QVY2; Eukaryota.
DR   HOGENOM; CLU_037388_4_0_1; -.
DR   InParanoid; A3KN25; -.
DR   OrthoDB; 1092887at2759; -.
DR   TreeFam; TF329606; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..275
FT                   /note="Gap junction gamma-3 protein"
FT                   /id="PRO_0000313007"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..77
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          254..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  30265 MW;  95FB995B5BE76CCD CRC64;
     MCGSFLRRVA AEESRHPTPV GRLLLPALLG LRLVLLAAGG TGVFGGGEEQ SEFVCHTQQA
     GCKAVCYDAF HPLSPLRFWA FQVTLVAVPS ALYMGFILYH VIWHWEASEK VKTEEETLSQ
     GEKGGEASRA GSSRLLWAYV AQLGVRLALE GAALGGQYHL YGFRMPSSFV CRLEPCLGST
     NCYLSRPSEK SIFLKTMFGV TGLCLLFTLL ELVLLGLGRW WRIWRHKSPS SNYSPTSQSA
     KRCKAPTDNF PVVEIRERPG EAGERGSEVP LSARP