CXG3_MOUSE
ID CXG3_MOUSE Reviewed; 269 AA.
AC Q921C1; Q53ZP5; Q8BHJ3;
DT 20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Gap junction gamma-3 protein;
DE AltName: Full=Connexin-29;
DE Short=Cx29;
DE AltName: Full=Gap junction epsilon-1 protein;
GN Name=Gjc3; Synonyms=Cx29, Gje1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=16926269; DOI=10.1152/physiolgenomics.00284.2005;
RA Wilson M.D., Cheung J., Martindale D.W., Scherer S.W., Koop B.F.;
RT "Comparative analysis of the paired immunoglobulin-like receptor (PILR)
RT locus in six mammalian genomes: duplication, conversion, and the birth of
RT new genes.";
RL Physiol. Genomics 27:201-218(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, and Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
RX PubMed=11501764; DOI=10.1515/bc.2001.122;
RA Soehl G., Eiberger J., Jung Y., Kozak C., Willecke K.;
RT "The mouse gap junction gene Connexin29 is highly expressed in sciatic
RT nerve and regulated during brain development.";
RL Biol. Chem. 382:973-978(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
RC STRAIN=129/SvEv;
RX PubMed=12151525; DOI=10.1523/jneurosci.22-15-06458.2002;
RA Altevogt B.M., Kleopa K.A., Postma F.R., Scherer S.S., Paul D.L.;
RT "Connexin29 is uniquely distributed within myelinating glial cells of the
RT central and peripheral nervous systems.";
RL J. Neurosci. 22:6458-6470(2002).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: CNS specific. Expression is restricted to brain,
CC spinal cord, and sciatic nerve.
CC -!- SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AY823670; AAX39497.1; -; Genomic_DNA.
DR EMBL; AY289210; AAP41202.1; -; mRNA.
DR EMBL; AY293564; AAP50246.1; -; mRNA.
DR EMBL; AY297108; AAP51160.1; -; mRNA.
DR EMBL; AK034037; BAC28554.1; -; mRNA.
DR EMBL; AK045577; BAC32421.1; -; mRNA.
DR EMBL; AK047368; BAC33038.1; -; mRNA.
DR EMBL; AK147913; BAE28224.1; -; mRNA.
DR EMBL; CH466529; EDL19225.1; -; Genomic_DNA.
DR EMBL; CH466529; EDL19226.1; -; Genomic_DNA.
DR EMBL; BC125305; AAI25306.1; -; mRNA.
DR EMBL; AJ297318; CAC29245.1; -; Genomic_DNA.
DR EMBL; AF503616; AAM21146.1; -; Genomic_DNA.
DR CCDS; CCDS19782.1; -.
DR RefSeq; NP_536698.2; NM_080450.4.
DR AlphaFoldDB; Q921C1; -.
DR SMR; Q921C1; -.
DR STRING; 10090.ENSMUSP00000076367; -.
DR TCDB; 1.A.24.1.12; the gap junction-forming connexin (connexin) family.
DR iPTMnet; Q921C1; -.
DR PhosphoSitePlus; Q921C1; -.
DR SwissPalm; Q921C1; -.
DR MaxQB; Q921C1; -.
DR PaxDb; Q921C1; -.
DR PeptideAtlas; Q921C1; -.
DR PRIDE; Q921C1; -.
DR ProteomicsDB; 284078; -.
DR Antibodypedia; 3109; 181 antibodies from 27 providers.
DR DNASU; 118446; -.
DR Ensembl; ENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
DR GeneID; 118446; -.
DR KEGG; mmu:118446; -.
DR UCSC; uc009aeg.1; mouse.
DR CTD; 349149; -.
DR MGI; MGI:2153041; Gjc3.
DR VEuPathDB; HostDB:ENSMUSG00000056966; -.
DR eggNOG; ENOG502QVY2; Eukaryota.
DR GeneTree; ENSGT01050000244962; -.
DR HOGENOM; CLU_037388_4_0_1; -.
DR InParanoid; Q921C1; -.
DR OMA; CYDAFHP; -.
DR OrthoDB; 1092887at2759; -.
DR PhylomeDB; Q921C1; -.
DR TreeFam; TF329606; -.
DR BioGRID-ORCS; 118446; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Gjc3; mouse.
DR PRO; PR:Q921C1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q921C1; protein.
DR Bgee; ENSMUSG00000056966; Expressed in lumbar subsegment of spinal cord and 55 other tissues.
DR Genevisible; Q921C1; MM.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0005921; C:gap junction; ISA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043209; C:myelin sheath; IDA:MGI.
DR GO; GO:0005243; F:gap junction channel activity; ISA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0007267; P:cell-cell signaling; ISA:MGI.
DR GO; GO:0042552; P:myelination; IMP:MGI.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..269
FT /note="Gap junction gamma-3 protein"
FT /id="PRO_0000354706"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 269 AA; 30293 MW; 13D9FF9C25C85D6A CRC64;
MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS GPGVFGNDEN
EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA IYVAFTLYHV IGYWEVPGKE
NKEQETQISK GDHSKDVSGA KSLKLLWAYV AHLGVRLALE GAALGVQYNL YGFKMSSTFI
CREDPCIGST TCFQSHPSEK TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF
LKKLPTSESS VRSKDTTDEL SVVEAKEPF
