CXL10_BOVIN
ID CXL10_BOVIN Reviewed; 102 AA.
AC Q2KIQ8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=C-X-C motif chemokine 10;
DE AltName: Full=Small-inducible cytokine B10;
DE Flags: Precursor;
GN Name=CXCL10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG U.S. Veterinary Immune Reagent Network;
RA Hudgens T., Tompkins D., Baldwin C.L.;
RT "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety
CC of processes such as chemotaxis, differentiation, and activation of
CC peripheral immune cells, regulation of cell growth, apoptosis and
CC modulation of angiostatic effects (By similarity). Plays thereby an
CC important role during viral infections by stimulating the activation
CC and migration of immune cells to the infected sites (By similarity).
CC Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G
CC protein-mediated signaling and results in downstream activation of
CC phospholipase C-dependent pathway, an increase in intracellular calcium
CC production and actin reorganization. In turn, recruitment of activated
CC Th1 lymphocytes occurs at sites of inflammation (By similarity).
CC Activation of the CXCL10/CXCR3 axis also plays an important role in
CC neurons in response to brain injury for activating microglia, the
CC resident macrophage population of the central nervous system, and
CC directing them to the lesion site. This recruitment is an essential
CC element for neuronal reorganization (By similarity).
CC {ECO:0000250|UniProtKB:P02778, ECO:0000250|UniProtKB:P17515}.
CC -!- SUBUNIT: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-
CC terminus). {ECO:0000250|UniProtKB:P02778}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02778}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; EU276062; ABX72060.1; -; mRNA.
DR EMBL; BC112547; AAI12548.1; -; mRNA.
DR RefSeq; NP_001040016.1; NM_001046551.2.
DR AlphaFoldDB; Q2KIQ8; -.
DR SMR; Q2KIQ8; -.
DR STRING; 9913.ENSBTAP00000039324; -.
DR PaxDb; Q2KIQ8; -.
DR Ensembl; ENSBTAT00000039533; ENSBTAP00000039324; ENSBTAG00000001725.
DR GeneID; 615107; -.
DR KEGG; bta:615107; -.
DR CTD; 3627; -.
DR VEuPathDB; HostDB:ENSBTAG00000001725; -.
DR VGNC; VGNC:27846; CXCL10.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR GeneTree; ENSGT00940000161759; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR InParanoid; Q2KIQ8; -.
DR OMA; RNIRCRC; -.
DR OrthoDB; 1548456at2759; -.
DR TreeFam; TF333433; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000001725; Expressed in abdominal lymph node and 99 other tissues.
DR ExpressionAtlas; Q2KIQ8; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0097398; P:cellular response to interleukin-17; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0042118; P:endothelial cell activation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR GO; GO:2000406; P:positive regulation of T cell migration; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:1901509; P:regulation of endothelial tube morphogenesis; IEA:Ensembl.
DR GO; GO:0010819; P:regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Citrullination; Cytokine; Disulfide bond;
KW Inflammatory response; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..102
FT /note="C-X-C motif chemokine 10"
FT /id="PRO_0000326171"
FT MOD_RES 24
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 28..55
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 30..72
FT /evidence="ECO:0000250|UniProtKB:P02778"
SQ SEQUENCE 102 AA; 11427 MW; 3371D2CE3A0B67FA CRC64;
MNKSGFLIFC LILLTLSQGV PLSRNTRCSC IEISNGSVNP RSLEKLEVIP ASQSCPRVEI
IATMKKNGEK RCLNPESKTI KNLLKAINKQ RTKRSPRTRK EA
