CXL10_CANLF
ID CXL10_CANLF Reviewed; 98 AA.
AC Q5KSV9;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=C-X-C motif chemokine 10;
DE AltName: Full=Small-inducible cytokine B10;
DE Flags: Precursor;
GN Name=CXCL10;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Tsukui T., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K.,
RA Sakaguchi M., Tsujimoto H., Iwabuchi S.;
RT "Expression analysis of CXCL10 gene in canine atopic dermatitis.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety
CC of processes such as chemotaxis, differentiation, and activation of
CC peripheral immune cells, regulation of cell growth, apoptosis and
CC modulation of angiostatic effects (By similarity). Plays thereby an
CC important role during viral infections by stimulating the activation
CC and migration of immune cells to the infected sites (By similarity).
CC Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G
CC protein-mediated signaling and results in downstream activation of
CC phospholipase C-dependent pathway, an increase in intracellular calcium
CC production and actin reorganization. In turn, recruitment of activated
CC Th1 lymphocytes occurs at sites of inflammation (By similarity).
CC Activation of the CXCL10/CXCR3 axis also plays an important role in
CC neurons in response to brain injury for activating microglia, the
CC resident macrophage population of the central nervous system, and
CC directing them to the lesion site. This recruitment is an essential
CC element for neuronal reorganization (By similarity).
CC {ECO:0000250|UniProtKB:P02778, ECO:0000250|UniProtKB:P17515}.
CC -!- SUBUNIT: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-
CC terminus). {ECO:0000250|UniProtKB:P02778}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02778}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; AB183191; BAD83839.1; -; mRNA.
DR RefSeq; NP_001010949.1; NM_001010949.1.
DR AlphaFoldDB; Q5KSV9; -.
DR SMR; Q5KSV9; -.
DR STRING; 9612.ENSCAFP00000032015; -.
DR PaxDb; Q5KSV9; -.
DR Ensembl; ENSCAFT00030026099; ENSCAFP00030022791; ENSCAFG00030014095.
DR Ensembl; ENSCAFT00040044270; ENSCAFP00040038650; ENSCAFG00040023780.
DR Ensembl; ENSCAFT00845052887; ENSCAFP00845041528; ENSCAFG00845029862.
DR GeneID; 478432; -.
DR KEGG; cfa:478432; -.
DR CTD; 3627; -.
DR VEuPathDB; HostDB:ENSCAFG00845029862; -.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR GeneTree; ENSGT00940000161759; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR InParanoid; Q5KSV9; -.
DR OMA; RNIRCRC; -.
DR OrthoDB; 1548456at2759; -.
DR TreeFam; TF333433; -.
DR Proteomes; UP000002254; Chromosome 32.
DR Bgee; ENSCAFG00000008584; Expressed in cardiac muscle of left ventricle and 43 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0097398; P:cellular response to interleukin-17; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0042118; P:endothelial cell activation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR GO; GO:2000406; P:positive regulation of T cell migration; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:1901509; P:regulation of endothelial tube morphogenesis; IEA:Ensembl.
DR GO; GO:0010819; P:regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Citrullination; Cytokine; Disulfide bond;
KW Inflammatory response; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..98
FT /note="C-X-C motif chemokine 10"
FT /id="PRO_0000045827"
FT MOD_RES 26
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 30..57
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 32..74
FT /evidence="ECO:0000250|UniProtKB:P02778"
SQ SEQUENCE 98 AA; 10895 MW; 22AD0151315EA619 CRC64;
MNQSAVLIFC LIFLTLNGTQ GIPLSRTIRC TCIKISDQPV NLRSLEKIEM IPASPSCPHV
EIIATMKKSG EKRCLNPESK TIKSLVKAIS KKRSRRSP
