ID   CXL10_MACMU             Reviewed;          98 AA.
AC   Q8MIZ1;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=C-X-C motif chemokine 10;
DE   AltName: Full=10 kDa interferon gamma-induced protein;
DE            Short=Gamma-IP10;
DE            Short=IP-10;
DE   AltName: Full=Small-inducible cytokine B10;
DE   Flags: Precursor;
GN   Name=CXCL10; Synonyms=SCYB10;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   Reinhart T.A., Fallert B.A., Pfeifer M., Capuano S. III, Rajakumar P.,
RA   Murphey-Corb M., Day R., Fuller C.L., Schaefer T.;
RT   "Increased expression of the interferon-gamma-inducible chemokine Mig/CXCL9
RT   in lymphoid tissues during simian immunodeficiency virus infection in
RT   vivo.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY044446; AAK95955.1; -; mRNA.
DR   RefSeq; NP_001028064.1; NM_001032892.1.
DR   AlphaFoldDB; Q8MIZ1; -.
DR   SMR; Q8MIZ1; -.
DR   STRING; 9544.ENSMMUP00000027500; -.
DR   ABCD; Q8MIZ1; 15 sequenced antibodies.
DR   GeneID; 574243; -.
DR   KEGG; mcc:574243; -.
DR   CTD; 3627; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   InParanoid; Q8MIZ1; -.
DR   OrthoDB; 1548456at2759; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Citrullination; Cytokine; Disulfide bond;
KW   Inflammatory response; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..98
FT                   /note="C-X-C motif chemokine 10"
FT                   /id="PRO_0000005103"
FT   MOD_RES         26
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10888 MW;  D760BC888BF72D9D CRC64;
     MNQTAILICC LVFLTLSGIQ GIPLSRTVRC TCISISNQPV NPRSLEKLEI IPPSQFCPHV
     EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP