ID   CXL10_MACNE             Reviewed;          98 AA.
AC   Q865F5;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=C-X-C motif chemokine 10;
DE   AltName: Full=10 kDa interferon gamma-induced protein;
DE            Short=Gamma-IP10;
DE            Short=IP-10;
DE   AltName: Full=Small-inducible cytokine B10;
DE   Flags: Precursor;
GN   Name=CXCL10;
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Coleman G.D., Clements J.E., Zink M.C.;
RT   "Macaca nemestrina interferon gamma-induced protein of 10 kDa (IP-10) (CXC
RT   chemokine).";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY206691; AAO52732.1; -; mRNA.
DR   RefSeq; NP_001295949.1; NM_001309020.1.
DR   AlphaFoldDB; Q865F5; -.
DR   SMR; Q865F5; -.
DR   STRING; 9545.ENSMNEP00000046238; -.
DR   GeneID; 105477263; -.
DR   CTD; 3627; -.
DR   Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Citrullination; Cytokine; Disulfide bond;
KW   Inflammatory response; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..98
FT                   /note="C-X-C motif chemokine 10"
FT                   /id="PRO_0000274966"
FT   MOD_RES         26
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10870 MW;  E1626C888BE015B5 CRC64;
     MNQTAILICC LVFLTLSGIQ GIPLSRTVRC TCISISNQPV NPRSLEKLEI IPPSQFCPHV
     EIIATMKKKG EKRCLNPESK AIKNLLKAVS EKKSKRPP