CXL10_RAT
ID CXL10_RAT Reviewed; 98 AA.
AC P48973; P70538; Q6GTC7;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=C-X-C motif chemokine 10;
DE AltName: Full=10 kDa interferon gamma-induced protein;
DE Short=Gamma-IP10;
DE Short=IP-10;
DE AltName: Full=Interferon-inducible protein 10;
DE AltName: Full=Protein Mob-1;
DE AltName: Full=Small-inducible cytokine B10;
DE Flags: Precursor;
GN Name=Cxcl10; Synonyms=Inp10, Mob1, Scyb10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7809069; DOI=10.1073/pnas.91.26.12515;
RA Liang P., Averboukh L., Zhu W., Pardee A.B.;
RT "Ras activation of genes: Mob-1 as a model.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:12515-12519(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8798675; DOI=10.1074/jbc.271.39.24286;
RA Wang X., Yue T.L., Ohlstein E.H., Sung C., Feuerstein G.Z.;
RT "Interferon-inducible protein-10 involves vascular smooth muscle cell
RT migration, proliferation, and inflammatory response.";
RL J. Biol. Chem. 271:24286-24293(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=30448292; DOI=10.1016/j.neulet.2018.11.021;
RA Chen Y., Yin D., Fan B., Zhu X., Chen Q., Li Y., Zhu S., Lu R., Xu Z.;
RT "Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in spinal
RT cord and dorsal root ganglia after chronic constriction injury in rats.";
RL Neurosci. Lett. 694:20-28(2018).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=30257241; DOI=10.1159/000493825;
RA Yu Q., Tian D.L., Tian Y., Zhao X.T., Yang X.Y.;
RT "Elevation of the Chemokine Pair CXCL10/CXCR3 Initiates Sequential Glial
RT Activation and Crosstalk During the Development of Bimodal Inflammatory
RT Pain after Spinal Cord Ischemia Reperfusion.";
RL Cell. Physiol. Biochem. 49:2214-2228(2018).
CC -!- FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety
CC of processes such as chemotaxis, differentiation, and activation of
CC peripheral immune cells, regulation of cell growth, apoptosis and
CC modulation of angiostatic effects (By similarity). Plays thereby an
CC important role during viral infections by stimulating the activation
CC and migration of immune cells to the infected sites (By similarity).
CC Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G
CC protein-mediated signaling and results in downstream activation of
CC phospholipase C-dependent pathway, an increase in intracellular calcium
CC production and actin reorganization. In turn, recruitment of activated
CC Th1 lymphocytes occurs at sites of inflammation (By similarity).
CC Activation of the CXCL10/CXCR3 axis also plays an important role in
CC neurons in response to brain injury for activating microglia, the
CC resident macrophage population of the central nervous system, and
CC directing them to the lesion site. This recruitment is an essential
CC element for neuronal reorganization (By similarity) (PubMed:30257241,
CC PubMed:30448292). {ECO:0000250|UniProtKB:P02778,
CC ECO:0000250|UniProtKB:P17515, ECO:0000269|PubMed:30257241,
CC ECO:0000269|PubMed:30448292}.
CC -!- SUBUNIT: Monomer, dimer, and tetramer. Interacts with CXCR3 (via N-
CC terminus). {ECO:0000250|UniProtKB:P02778}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02778}.
CC -!- TISSUE SPECIFICITY: In the central nervous system, CXCL10 is
CC predominantly localized to activated neurons (PubMed:30448292).
CC Expressed in both microglia and astrocytes (PubMed:30257241).
CC {ECO:0000269|PubMed:30257241, ECO:0000269|PubMed:30448292}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; U17035; AAB60485.1; -; mRNA.
DR EMBL; U22520; AAC52811.1; -; mRNA.
DR EMBL; BC058444; AAH58444.1; -; mRNA.
DR RefSeq; NP_620789.1; NM_139089.1.
DR AlphaFoldDB; P48973; -.
DR SMR; P48973; -.
DR STRING; 10116.ENSRNOP00000003649; -.
DR PaxDb; P48973; -.
DR Ensembl; ENSRNOT00000003075; ENSRNOP00000003649; ENSRNOG00000022256.
DR GeneID; 245920; -.
DR KEGG; rno:245920; -.
DR UCSC; RGD:620209; rat.
DR CTD; 3627; -.
DR RGD; 620209; Cxcl10.
DR eggNOG; ENOG502S7MM; Eukaryota.
DR GeneTree; ENSGT00940000161759; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR InParanoid; P48973; -.
DR OMA; RNIRCRC; -.
DR OrthoDB; 1548456at2759; -.
DR PhylomeDB; P48973; -.
DR TreeFam; TF333433; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:P48973; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000022256; Expressed in spleen and 19 other tissues.
DR Genevisible; P48973; RN.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; TAS:RGD.
DR GO; GO:0008201; F:heparin binding; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; ISO:RGD.
DR GO; GO:0034605; P:cellular response to heat; IEP:RGD.
DR GO; GO:0097398; P:cellular response to interleukin-17; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0098586; P:cellular response to virus; ISO:RGD.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR GO; GO:0042118; P:endothelial cell activation; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006955; P:immune response; IDA:RGD.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IDA:RGD.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; ISO:RGD.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IDA:RGD.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; ISO:RGD.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR GO; GO:2000406; P:positive regulation of T cell migration; ISO:RGD.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:1901509; P:regulation of endothelial tube morphogenesis; ISO:RGD.
DR GO; GO:0010819; P:regulation of T cell chemotaxis; ISO:RGD.
DR GO; GO:0010996; P:response to auditory stimulus; IEP:RGD.
DR GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR GO; GO:0009409; P:response to cold; IEP:RGD.
DR GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0009615; P:response to virus; IEP:RGD.
DR GO; GO:0033280; P:response to vitamin D; IEP:RGD.
DR GO; GO:0010818; P:T cell chemotaxis; ISO:RGD.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Citrullination; Cytokine; Disulfide bond;
KW Inflammatory response; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..98
FT /note="C-X-C motif chemokine 10"
FT /id="PRO_0000005105"
FT MOD_RES 26
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 30..57
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT DISULFID 32..74
FT /evidence="ECO:0000250|UniProtKB:P02778"
FT CONFLICT 39
FT /note="P -> T (in Ref. 1; AAB60485)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 10729 MW; 5CAF8790695F72D5 CRC64;
MNPSAAVVLC LVLLSLSGTQ GIPLARTVRC TCIDFHEQPL RPRAIGKLEI IPASLSCPHV
EIIATMKKNN EKRCLNPESE AIKSLLKAVS QRRSKRAP
