ID   CXL11_BOVIN             Reviewed;         100 AA.
AC   A9QWQ1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=C-X-C motif chemokine 11;
DE   AltName: Full=Small-inducible cytokine B11;
DE   Flags: Precursor;
GN   Name=CXCL11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG   U.S. Veterinary Immune Reagent Network;
RA   Hudgens T., Tompkins D., Baldwin C.L.;
RT   "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic for interleukin-activated T-cells but not
CC       unstimulated T-cells, neutrophils or monocytes. Induces calcium release
CC       in activated T-cells. Binds to CXCR3. May play an important role in CNS
CC       diseases which involve T-cell recruitment. May play a role in skin
CC       immune responses (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TNFAIP6 (via Link domain).
CC       {ECO:0000250|UniProtKB:O14625}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; EU276063; ABX72061.1; -; mRNA.
DR   RefSeq; NP_001106644.1; NM_001113173.1.
DR   AlphaFoldDB; A9QWQ1; -.
DR   SMR; A9QWQ1; -.
DR   STRING; 9913.ENSBTAP00000034148; -.
DR   PaxDb; A9QWQ1; -.
DR   Ensembl; ENSBTAT00000034249; ENSBTAP00000034148; ENSBTAG00000005603.
DR   GeneID; 516104; -.
DR   KEGG; bta:516104; -.
DR   CTD; 6373; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005603; -.
DR   VGNC; VGNC:27847; CXCL11.
DR   eggNOG; ENOG502SGFE; Eukaryota.
DR   GeneTree; ENSGT00530000064263; -.
DR   HOGENOM; CLU_143902_2_3_1; -.
DR   InParanoid; A9QWQ1; -.
DR   OMA; IFCATIA; -.
DR   TreeFam; TF333433; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000005603; Expressed in abdominal lymph node and 85 other tissues.
DR   ExpressionAtlas; A9QWQ1; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010818; P:T cell chemotaxis; IEA:Ensembl.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR027221; CXCL11.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   PANTHER; PTHR10179:SF28; PTHR10179:SF28; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..100
FT                   /note="C-X-C motif chemokine 11"
FT                   /id="PRO_0000326170"
FT   DISULFID        30..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  10943 MW;  7FF6C292B391D5FB CRC64;
     MSVKGMAIVL TVILCAAIVQ GFPMFKGGRC LCIGPGVKAV KVADIEKVSI IYPTNNCDKT
     EVIITLKTHK GQRCLNPKAK QAKAIIKKVQ RKNSEKYKNI