CXL11_MOUSE
ID CXL11_MOUSE Reviewed; 100 AA.
AC Q9JHH5;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=C-X-C motif chemokine 11;
DE AltName: Full=Interferon-inducible T-cell alpha chemoattractant;
DE Short=I-TAC;
DE AltName: Full=Small-inducible cytokine B11;
DE Flags: Precursor;
GN Name=Cxcl11; Synonyms=Scyb11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10828609; DOI=10.1159/000015538;
RA Meyer M., Erdel M., Duba H.C., Werner E.R., Werner-Felmayer G.;
RT "Cloning, genomic sequence, and chromosome mapping of scyb11, the murine
RT homologue of SCYB11 (alias betaR1/H174/SCYB9B/I-TAC/IP-9/CXCL11).";
RL Cytogenet. Cell Genet. 88:278-282(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10843686; DOI=10.4049/jimmunol.164.12.6322;
RA Widney D.P., Xia Y.-R., Lusis A.J., Smith J.B.;
RT "The murine chemokine CXCL11 (IFN-inducible T cell alpha chemoattractant)
RT is an IFN-gamma- and lipopolysaccharide-inducible glucocorticoid-attenuated
RT response gene expressed in lung and other tissues during endotoxemia.";
RL J. Immunol. 164:6322-6331(2000).
CC -!- FUNCTION: Chemotactic for interleukin-activated T-cells but not
CC unstimulated T-cells, neutrophils or monocytes. Induces calcium release
CC in activated T-cells. Binds to CXCR3. May play an important role in CNS
CC diseases which involve T-cell recruitment. May play a role in skin
CC immune responses (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TNFAIP6 (via Link domain).
CC {ECO:0000250|UniProtKB:O14625}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
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DR EMBL; AF178672; AAF79048.1; -; mRNA.
DR EMBL; AF167354; AAF71824.1; -; Genomic_DNA.
DR EMBL; AF179872; AAF77095.1; -; mRNA.
DR EMBL; AF136449; AAF79022.1; -; mRNA.
DR RefSeq; NP_062367.1; NM_019494.1.
DR AlphaFoldDB; Q9JHH5; -.
DR SMR; Q9JHH5; -.
DR PhosphoSitePlus; Q9JHH5; -.
DR PRIDE; Q9JHH5; -.
DR DNASU; 56066; -.
DR GeneID; 56066; -.
DR KEGG; mmu:56066; -.
DR CTD; 6373; -.
DR MGI; MGI:1860203; Cxcl11.
DR InParanoid; Q9JHH5; -.
DR PhylomeDB; Q9JHH5; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 56066; 1 hit in 21 CRISPR screens.
DR PRO; PR:Q9JHH5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9JHH5; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR027221; CXCL11.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR PANTHER; PTHR10179:SF28; PTHR10179:SF28; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..100
FT /note="C-X-C motif chemokine 11"
FT /id="PRO_0000005107"
FT DISULFID 30..57
FT /evidence="ECO:0000250"
FT DISULFID 32..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 100 AA; 11266 MW; 9932345FD5F1E5E9 CRC64;
MNRKVTAIAL AAIIWATAAQ GFLMFKQGRC LCIGPGMKAV KMAEIEKASV IYPSNGCDKV
EVIVTMKAHK RQRCLDPRSK QARLIMQAIE KKNFLRRQNM
