CXL13_HUMAN
ID CXL13_HUMAN Reviewed; 109 AA.
AC O43927;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=C-X-C motif chemokine 13;
DE AltName: Full=Angie;
DE AltName: Full=B cell-attracting chemokine 1;
DE Short=BCA-1;
DE AltName: Full=B lymphocyte chemoattractant;
DE AltName: Full=CXC chemokine BLC;
DE AltName: Full=Small-inducible cytokine B13;
DE Flags: Precursor;
GN Name=CXCL13; Synonyms=BCA1, BLC, SCYB13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9486651; DOI=10.1038/35876;
RA Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.;
RT "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's
RT lymphoma receptor-1.";
RL Nature 391:799-803(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=9463416; DOI=10.1084/jem.187.4.655;
RA Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M.,
RA Moser B.;
RT "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid
RT tissues, selectively attracts B lymphocytes via BLR1/CXCR5.";
RL J. Exp. Med. 187:655-660(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood;
RA Napolitano M., Spinetti G., Gaetano C., Capogrossi C.M.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Chemotactic for B-lymphocytes but not for T-lymphocytes,
CC monocytes and neutrophils. Does not induce calcium release in B-
CC lymphocytes. Binds to BLR1/CXCR5.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highest levels in liver, followed by spleen, lymph
CC node, appendix and stomach. Low levels in salivary gland, mammary gland
CC and fetal spleen.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CXCL13 entry;
CC URL="https://en.wikipedia.org/wiki/CXCL13";
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DR EMBL; AF044197; AAC14402.1; -; mRNA.
DR EMBL; AJ002211; CAA05250.1; -; mRNA.
DR EMBL; AF029894; AAC17980.1; -; mRNA.
DR EMBL; BC012589; AAH12589.1; -; mRNA.
DR CCDS; CCDS3582.1; -.
DR RefSeq; NP_006410.1; NM_006419.2.
DR RefSeq; XP_006714126.1; XM_006714063.3.
DR PDB; 5CBA; X-ray; 2.50 A; E/F=23-109.
DR PDB; 5CBE; X-ray; 2.40 A; E/F=23-109.
DR PDB; 6VGJ; X-ray; 2.52 A; A/B/C/D/E/F/G=24-109.
DR PDB; 7JNY; X-ray; 1.88 A; A=23-109.
DR PDBsum; 5CBA; -.
DR PDBsum; 5CBE; -.
DR PDBsum; 6VGJ; -.
DR PDBsum; 7JNY; -.
DR AlphaFoldDB; O43927; -.
DR SMR; O43927; -.
DR BioGRID; 115814; 12.
DR DIP; DIP-5914N; -.
DR IntAct; O43927; 9.
DR MINT; O43927; -.
DR STRING; 9606.ENSP00000286758; -.
DR iPTMnet; O43927; -.
DR PhosphoSitePlus; O43927; -.
DR BioMuta; CXCL13; -.
DR jPOST; O43927; -.
DR MassIVE; O43927; -.
DR PaxDb; O43927; -.
DR PeptideAtlas; O43927; -.
DR PRIDE; O43927; -.
DR ProteomicsDB; 49240; -.
DR ABCD; O43927; 4 sequenced antibodies.
DR Antibodypedia; 13544; 556 antibodies from 39 providers.
DR CPTC; O43927; 1 antibody.
DR DNASU; 10563; -.
DR Ensembl; ENST00000286758.4; ENSP00000286758.4; ENSG00000156234.8.
DR Ensembl; ENST00000682537.1; ENSP00000507688.1; ENSG00000156234.8.
DR GeneID; 10563; -.
DR KEGG; hsa:10563; -.
DR MANE-Select; ENST00000682537.1; ENSP00000507688.1; NM_001371558.1; NP_001358487.1.
DR CTD; 10563; -.
DR DisGeNET; 10563; -.
DR GeneCards; CXCL13; -.
DR HGNC; HGNC:10639; CXCL13.
DR HPA; ENSG00000156234; Tissue enriched (lymphoid).
DR MIM; 605149; gene.
DR neXtProt; NX_O43927; -.
DR OpenTargets; ENSG00000156234; -.
DR PharmGKB; PA35570; -.
DR VEuPathDB; HostDB:ENSG00000156234; -.
DR eggNOG; ENOG502SEXJ; Eukaryota.
DR GeneTree; ENSGT00530000064292; -.
DR HOGENOM; CLU_143902_2_0_1; -.
DR InParanoid; O43927; -.
DR OMA; VNPDAPW; -.
DR OrthoDB; 1510748at2759; -.
DR PhylomeDB; O43927; -.
DR TreeFam; TF335204; -.
DR PathwayCommons; O43927; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; O43927; -.
DR BioGRID-ORCS; 10563; 11 hits in 1053 CRISPR screens.
DR ChiTaRS; CXCL13; human.
DR GeneWiki; CXCL13; -.
DR GenomeRNAi; 10563; -.
DR Pharos; O43927; Tbio.
DR PRO; PR:O43927; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; O43927; protein.
DR Bgee; ENSG00000156234; Expressed in spleen and 132 other tissues.
DR ExpressionAtlas; O43927; baseline and differential.
DR Genevisible; O43927; HS.
DR GO; GO:0005576; C:extracellular region; IDA:BHF-UCL.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031735; F:CCR10 chemokine receptor binding; IDA:BHF-UCL.
DR GO; GO:0008009; F:chemokine activity; IDA:BHF-UCL.
DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IPI:BHF-UCL.
DR GO; GO:0031724; F:CXCR5 chemokine receptor binding; IDA:BHF-UCL.
DR GO; GO:0017134; F:fibroblast growth factor binding; IDA:BHF-UCL.
DR GO; GO:0008201; F:heparin binding; IDA:BHF-UCL.
DR GO; GO:0048018; F:receptor ligand activity; IDA:BHF-UCL.
DR GO; GO:0090630; P:activation of GTPase activity; ISS:BHF-UCL.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR GO; GO:0035754; P:B cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:0007267; P:cell-cell signaling; IDA:BHF-UCL.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0002544; P:chronic inflammatory response; NAS:BHF-UCL.
DR GO; GO:0042742; P:defense response to bacterium; IDA:BHF-UCL.
DR GO; GO:0035768; P:endothelial cell chemotaxis to fibroblast growth factor; IDA:BHF-UCL.
DR GO; GO:0002467; P:germinal center formation; NAS:BHF-UCL.
DR GO; GO:0006955; P:immune response; IC:BHF-UCL.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR GO; GO:0002518; P:lymphocyte chemotaxis across high endothelial venule; ISS:BHF-UCL.
DR GO; GO:2000545; P:negative regulation of endothelial cell chemotaxis to fibroblast growth factor; IDA:BHF-UCL.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; ISS:BHF-UCL.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:BHF-UCL.
DR GO; GO:0033625; P:positive regulation of integrin activation; ISS:BHF-UCL.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0045765; P:regulation of angiogenesis; NAS:BHF-UCL.
DR GO; GO:0002920; P:regulation of humoral immune response; NAS:BHF-UCL.
DR CDD; cd00273; Chemokine_CXC; 1.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR10179; PTHR10179; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..109
FT /note="C-X-C motif chemokine 13"
FT /id="PRO_0000005113"
FT DISULFID 33..60
FT /evidence="ECO:0000250"
FT DISULFID 35..76
FT /evidence="ECO:0000250"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:7JNY"
FT STRAND 35..37
FT /evidence="ECO:0007829|PDB:5CBE"
FT HELIX 45..47
FT /evidence="ECO:0007829|PDB:7JNY"
FT STRAND 48..54
FT /evidence="ECO:0007829|PDB:7JNY"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:6VGJ"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:5CBE"
FT STRAND 64..69
FT /evidence="ECO:0007829|PDB:7JNY"
FT STRAND 74..77
FT /evidence="ECO:0007829|PDB:7JNY"
FT HELIX 82..93
FT /evidence="ECO:0007829|PDB:7JNY"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:6VGJ"
SQ SEQUENCE 109 AA; 12664 MW; 4057FCA8EFF658A8 CRC64;
MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC
PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP
